the genetic polymorphism of some genes related to meat production in three egyptian sheep breeds (barki, rahmani and osseimi) was studied. the candidate genes were: calpastatin, myostatin, diacylglycerol-acyltransferase1, insulin-like growth factor binding protein-3 and booroola fecundity gene. the technique applied was the restriction fragment length polymorphism for the polymerase chain react...

The growth hormone (GH)–insulin-like factor (IGF) axis is one of the main drivers mammalian and development. Pituitary secretion GH pulsatile under positive negative hypothalamic control, as well stimulation from gastric-secreted acyl-ghrelin. acts both directly via GH-receptor (GHR) indirectly IGF1 production to induce anabolic metabolic responses at multiple target tissues. In this review, we...

OBJECTIVE Pregnancy associated plasma protein-A2 (PAPP-A2) is a protease that cleaves insulin-like growth factor binding protein-5 (IGFBP-5), the most abundant IGFBP in bone. Deletion of Pappa2 reduces postnatal growth and bone length in mice. The aim of this study was to determine whether locally produced PAPP-A2 is required for normal bone growth. DESIGN We deleted Pappa2 primarily in osteo...