Target-based drug discovery must assess many drug-like compounds for potential activity. Focusing on low-molecular-weight compounds (fragments) can dramatically reduce the chemical search space. However, approaches for determining protein-fragment interactions have limitations. Experimental assays are time-consuming, expensive, and not always applicable. At the same time, computational approach...

We have determined the amino acid sequence of the amino-terminal 67,000-dalton (67-kDa) fragment of human ceruloplasmin and have established overlapping sequences between the 67-kDa and 50-kDa fragments and between the 50-kDa and 19-kDa fragments. The 67-kDa fragment contains 480 amino acid residues and three glucosamine oligosaccharides. These results together with our previous sequence data f...

We formulate a formal syntax of approximate formulas for the logic with counting quantifiers, SOLP, studied by us in [1], where we showed the following facts: (i) In the presence of a built–in (linear) order, SOLP can describe NP–complete problems and fragments of it capture classes like P andNL; (ii) weakening the ordering relation to an almost order (in the sense of [7]) we can separate meani...

BACKGROUND AA amyloidosis develops in patients with chronic inflammatory diseases. The AA amyloid proteins are proteolytic fragments obtained from serum amyloid A (SAA). Previous studies have provided evidence that endosomes or lysosomes might be involved in the processing of SAA, and contribute to the pathology of AA amyloidosis. OBJECTIVE To investigate the anatomical distribution of cathep...

The conversion of peptide and proteins from their soluble state into well-organized aggregates, together with the accompanied oxidation of methionine residue, presents a significant challenge to human health, to the manufacture of protein therapeutics, and to the synthesis of proteins and glycoproteins. Despite their fundamental importance, little is known about the molecular basis of these two...

The villin headpiece helical subdomain (HP36) is one of the best known model systems for computational studies of fast-folding all-α miniproteins. HP21 is a peptide fragment-derived from HP36-comprising only the first and second helices of the full domain. Experimental studies showed that although HP21 is mostly unfolded in solution, it does maintain some persistent native-like structure as ind...

background: filamentous hemagglutinin (fha) is one of the most important immunoprotective antigens of bordetella pertussis (b.pertussis) and a major component of the acellular pertussis vaccine. in the present study, three overlapping recombinant fragments from the immunodominant region of fha were produced and their immunogenicity was investigated. methods: three overlapping coding sequences o...

Lunar highland meteorites contain small proportions of mare basalt fragments, which are important for defining lunar basalts in areas not visited by Apollo/Luna. We analyzed seven mare basalt fragments from three highland meteorites, and retrieved the Ti contents of their parent magmas from core pyroxene compositions. The analyzed clasts span the range of VLT and low-Ti, basalts in Apollo & Lun...

This is a review of The Marrow Longing by dancer/poet/writer/educator, Celeste Nazeli Snowber. book, presented in fragments, heartrending and thought-provoking poetic visual inquiry into Celeste’s motherline, Armenian cultural heritage, identity. It will awaken, like it has for me, your longings need to become aware what formed informed own life. both an offering/gift invitation.

The majority of C1q-binding IgG in sera of some patients with systemic lupus erythematosus (SLE) cosediments with monomeric IgG. This study was undertaken to provide definitive proof that the low-molecular weight C1q-binding IgG consists of autoantibodies to C1q. Monomeric C1q-binding IgG was isolated from five SLE plasmas by C1q affinity chromatography and gel filtration. All C1q-binding IgG p...