Regulated aggregations of prion and prion-like proteins play physiological roles in various biological processes. However, their structural roles in the nucleus are poorly understood. Here, we show that the prion-like protein Jub6p is involved in the regulation of chromatin structure in the ciliated protozoan Tetrahymena thermophila Jub6p forms sodium dodecyl sulfate (SDS)-resistant aggregates ...

On feeding to splenectomized dogs a diet producing black tongue, severe anemia developed associated with the presence of small bodies in or on the erythrocytes. The bodies were morphologically similar to Bartonella muris and Bartonella canis. The addition of lean beef to the diet, a material prophylactic against its effects, was followed by improvement of the blood levels, the presence of incre...

context:micrornas (mirnas) are a class of short, endogenously-initiated, non-coding rnas that post-transcriptionally control gene expression via translational repression or mrna turnover. mirnas have attracted much attention in recent years as they play critical roles in gene expression and are promising tools with many biotech and therapeutic applications. the molecular mechanisms underlying t...

Processing bodies (P-bodies) are cytoplasmic granules involved in the storage and degradation of mRNAs. In somatic cells, their formation involves miRNA-mediated mRNA silencing. Many P-body protein components are also found in germ cell granules, such as in mammalian spermatocytes. In fully grown mammalian oocytes, where changes in gene expression depend entirely on translational control, RNA g...

Bacterial inclusion bodies, while showing intriguing amyloid-like features, such as a beta-sheet-based intermolecular organization, binding to amyloid-tropic dyes, and origin in a sequence-selective deposition process, hold an important amount of native-like secondary structure and significant amounts of functional polypeptides. The aggregation mechanics supporting the occurrence of both misfol...

The role of geometry on dispersive forces is investigated by calculating the energy between different spheroidal particles and planar surfaces, both with arbitrary dielectric properties. The energy is obtained in the non-retarded limit using a spectral representation formalism and calculating the interaction between the surface plasmons of the two macroscopic bodies. The energy is a power-law f...

Characteristic tubular bodies were detected with great regularity in the endothelial cells of the blood vessels of human eyes, normal and pathologic, as well as in growing vessels in rabbit corneas. These bodies in the mature form are shaped like a cylindrical rod with an internal tubular structure, bounded by a limiting membrane of unit membrane type. They are numerous in some instances of Beh...

We analyzed transmission electron micrographs of human lung mast cells by digitized planimetry and point counting to determine the cross-sectional areas of two distinct cytoplasmic organelles: specific granules and lipid bodies. Specific granules have a limiting membrane and often contain one or more cylindrical scroll-like inclusions. By contrast, lipid bodies are on average much larger than g...

placement of narcotics inside intestinal tract of passengers and their illegal transfer through police stations and customs is called body packer or body bagger syndrome.in other parts of the world transfer of cocaine by this method has been reported.this prospective study was done with the help of Anti-narcotic Agency on the transfer of opium and heroin packages from Fenruary 1996 to January 1...