Differential-difference equations (DDEs) of the form u n (t) = Fn(t, un+a, . . . , un+b) with k ≥ 2 are studied for Lie symmetries and preliminary classification. Explicit forms of equations are given for those admitting at least one intrinsic Lie symmetry. An algorithmic mechanism is also proposed to automate the symmetry calculation for fairly general DDEs via computer algebras.