Marked Na(+)/Li(+) countertransport hyperactivity and post-load hyperinsulinaemia have been described in 93% of patients with cardiac syndrome X. We hypothesized that more complex abnormalities in Na(+) traffic across the cell membrane are present in these patients. The aim of the present study was to evaluate the activities of the two main transporters responsible for transmembrane Na(+) trans...

Parathyroid hormone (PTH) release from parathyroid cells in vitro was found to be stimulated by the presence of extracellular lithium ions through a specific secretory response which was comparable to that elicited by low extracellular Ca2+. Li+ (5-40 mM) caused a dramatic increase in the basal PTH secretory rate (up to 2.5-fold), as well as a further enhancement of the low Ca2+-stimulated PTH ...

We present calculations for the static structure and ordering properties of two lithium-based s-p bonded liquid alloys, Li-Na and Li-Mg. Our theoretical approach is based on the neutral pseudoatom method to derive the interatomic pair potentials, and on the modified-hypernetted-chain theory of liquids to obtain the liquid static structure, leading to a whole combination that is free of adjustab...

In the present study, an investigation on the complex formation between mono- and divalent metal ions (Na+, K+, Li+ and Mg2+) in the form of salt with different podands using various solvents has been carried out.  Isolated complexes were characterized by different spectroscopic techniques viz. IR, NMR and elemental analysis. On the basis of ...

The vacuole-type ATPases (V-ATPases) are proton pumps in various intracellular compartments of eukaryotic cells. Prokaryotic V-ATPase of Enterococcus hirae, closely related to the eukaryotic enzymes, provides a unique opportunity to study ion translocation by V-ATPases because it transports Na(+) ions, which are easier to detect by x-ray crystallography and radioisotope experiments. The purifie...

Pretreatment of isolated human neutrophils (resting pHi congruent to 7.25 at pHo 7.40) with 30 mM NH4Cl for 30 min leads to an intracellular acidification (pHi congruen to 6.60) when the NH4Cl prepulse is removed. Thereafter, in 140 mM Na+ medium, pHi recovers exponentially with time (initial rate, approximately 0.12 pH/min) to reach the normal resting pHi by approximately 20 min, a process tha...

The epithelial Na 1 channel (ENaC) is highly selective for Na 1 and Li 1 over K 1 and is blocked by the diuretic amiloride. ENaC is a heterotetramer made of two a , one b , and one g homologous subunits, each subunit comprising two transmembrane segments. Amino acid residues involved in binding of the pore blocker amiloride are located in the pre-M2 segment of b and g subunits, which precedes t...

The effect of lithium ions on cardiac cells was investigated by recording the changes in transmembrane potential and by following the movement of Li, Na, and K across the cell membrane. Isolated preparations of calf Purkinje fibers and cat ventricular muscles were used. Potentials were measured by intracellular microelectrodes; ion transport was estimated by flame photometric analysis and by us...

A new class of redox-switched anthraquinone derived lariat ethers 1-(1-anthraquinonyloxy) 3, 6, 9 trioxaundecane 11-ol (M(1)), 1-(1-anthraquinonyloxy) 3, 6 dioxaoctane 9-ol (M(2)), 1-(1-anthraquinonyloxy) 3 oxapentane 5-ol (M(3)), 1-(1-anthraquinonyloxy) 3 oxapentane 5-butane (M(4)), 1-(1-anthraquinonyloxy) 3, 6 dioxaoctane 9-methane (M(5)) and 1-(1-anthraquinonyloxy) 3 oxapentane 5-methane (M(...

A series of alkali metal cerium diphenylhydrazido complexes, Mx(py)y[Ce(PhNNPh)4], M 1⁄4 Li, Na, and K, x 1⁄4 4 (Li and Na) or 5 (K), and y1⁄4 4 (Li), 8 (Na), or 7 (K), were synthesized to probe how a secondary coordination sphere would modulate electronic structures at a cerium cation. The resulting electronic structures of the heterobimetallic cerium diphenylhydrazido complexes were found to ...