Piracy is a persistent headache for software companies that try to protect their assets by investing both time and money. Program code obfuscation as a sub-field of software protection is a mechanism widely used toward this direction. However, effectively protecting a program against reverse-engineering and tampering turned out to be a highly non-trivial task that still is subject to ongoing re...

BACKGROUND ATP13A2 (PARK9) loss of function mutations are a genetic cause of an early-onset form of Parkinson's disease (PD), with in vitro studies showing that ATP13A2 deficits lead to lysosomal and mitochondrial dysfunction and α-synuclein accumulation, while elevated ATP13A2 expression reduces α-synuclein toxicity. The three human brain tissue studies assessing changes in ATP13A2 expression ...

BACKGROUND Olfactory abnormalities are reported in Alzheimer's disease and Parkinson's disease. Anosmia appears to be common in dementia with Lewy bodies but not in pure Alzheimer's disease. OBJECTIVE To determine whether anosmia improves discrimination between the Lewy body variant (LBV) of Alzheimer's disease and "pure" Alzheimer's disease. METHODS 106 cases of necropsy confirmed pure Alz...

INTRODUCTION Rapid eye movement sleep behavior disorder (RBD) is strongly associated with synucleinopathies. In 2012, we reported an increased risk of mild cognitive impairment (MCI) and Parkinson disease (PD) in cognitively normal Olmsted County, Minnesota, residents, aged 70 to 89 years with probable RBD. Here, we examine their progression to dementia and other neurodegenerative phenotypes. ...

This paper investigates the use of a special class of strong-stability-preserving (SSP) Runge–Kutta time discretization methods in conjunction with discontinuous Galerkin (DG) finite element spatial discretizatons. The class of SSP methods investigated here is defined by the property that the number of stages s is greater than the order k of the method. From analysis, CFL conditions for the lin...

A purified Shigella enterotoxin (pST) and a cell-free lysate with pST removed (CFL-pST) from the whole-cell lysate of Shigella dysenteriae 60 R were used to study their effect on the myoelectric activity and mucosal integrity of rabbit ileal segments. We have previously defined two myoelectric patterns: the migrating action potential complex and repetitive bursts of action potentials that occur...

This study examined the effects of red blood cell (RBC) aggregation at pathological levels on NO/O2 transport in small arterioles. Transient gas diffusion simulations were performed with in vivo cell-free layer (CFL) widths data obtained from arteriolar flows in the rat cremaster muscle. The CFL data were measured at physiological and pathological levels of aggregation under reduced flow condit...

In 1913, the Breslau neurologist Lewy described globular inclusions of cytoplasmic condensations in the cells of the nucleus substantiae innominatae and the dorsal vagal nucleus in paralysis agitans. These cell inclusions have since been described by many other investigators. In 1923, Lewy also found them in the pigmented ganglion cells of the substantia nigra in Parkinson's disease. Tretiakoff...

Seeking antemortem markers to distinguish Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD), we examined brain glucose metabolism of DLB and AD. Eleven DLB patients (7 Lewy body variant of AD [LBVAD] and 4 pure diffuse Lewy body disease [DLBD]) who had antemortem position emission tomography imaging and autopsy confirmation were compared to 10 autopsy-confirmed pure AD patients. In a...