chemokines are classified in four distinct groups as cxc, cc, cx3c and c, depending on the presence or absence of a motif called elr (arg-leu-glu) before the first cysteine residue in their structure. cxc chemokines are also subdivided into elr + and elr - . increasing evidence has indicated the existence of a chemokine network in the liver which is involved in both physiological responses and,...

there are limited clinical investigations identifying the percentage of t helper 1 (th1) and t regulatory (treg) cells in stable as well as rejected kidney allografts, a concept which needs to be more studied. the aim of our study was to compare the percentage of cd4+ ifn-γ+ cells, the number of ifn-γ secreting cells and the amount of foxp3 expression in patients with or without stable graft fu...

The administration of interferon has improved the antiviral and immunomodulatory abilities piglets, which is conductive to prevention potential diseases or delay appearance clinical symptoms. This study aimed evaluate effects from recombinant interferon-alpha (IFN-α) on daily care piglets. results were compared a Chinese herbal drug that was shown increase serum levels. In addition, routes oral...

To explore the role of Toll-like receptors (TLRs) and interferon (IFN) in innate immunity against porcine epidemic diarrhea virus (PEDV), we detected expression TLR genes PEDV-infected IPEC-J2 cells by real-time PCR. We also level α (IFN-α) γ (IFN-γ) enzyme-linked immunosorbent assay (ELISA). Results showed that exhibited a clear pathological change after PEDV infection at 24 h. In addition, TL...

interferon (ifn)-based therapy, the cornerstone for treatment of hepatitis c virus (hcv) infection, is generally considered to be the single most effective treatment strategy for this infection. although most adverse effects of ifn therapy respond very well to the cessation of this drug, there are reports of serious irreversible adverse effects. this review article evaluates the adverse effects...