نتایج جستجو برای: leukotriene antagonists

تعداد نتایج: 55425  

2011
John M. Kelso

METHODS. This was a randomized, multicenter, doubleblind, placebo-controlled study for patients who received either 5-mg montelukast or placebo beginning on the night before school started and continued for an 8-week period. Patients were randomly assigned during a screening period from 2 to 12 weeks before the school start date. Patients were interviewed by telephone to review symptoms, use of...

Journal: :Internal medicine 2012
Takashi Hasegawa Toshiyuki Koya Takuro Sakagami Shinichi Toyabe Hiroshi Kagamu Masaaki Arakawa Fumitake Gejyo Ichiei Narita Eiichi Suzuki

BACKGROUND Despite the advances of asthma management and the accompanying improved asthma control, many problems related to asthma management still remain. The Niigata Asthma Treatment Study Group has been regularly collecting information via surveys since 1998 using a questionnaire, on problems related to asthma management; various studies on asthma management have been reported using data fro...

Journal: :Journal of immunology 2009
Eric Gaudreault Jean Gosselin

TLRs are known to be important in innate host defense against a variety of microbial infections. In particular, TLR9 has been associated with immune defense against different foreign organisms by recognition of unmethylated DNA sequences. In this report, we provide evidence that leukotriene B(4) (LTB(4)) has the capacity to modulate TLR9 expression on human neutrophils. The effect of LTB(4) was...

Journal: :PPAR Research 2008
Masamichi Yamashita

Peroxisome proliferator-activated receptor (PPAR) alpha ligands (Wy-14,643, and fenofibrate) and PPARgamma ligands (troglitazone and ciglitazone) inhibit antigen-induced cysteinyl leukotriene production in immunoglobulin E-treated mast cells. The inhibitory effect of these ligands on cysteinyl leukotriene production is quite strong and is almost equivalent to that of the anti-asthma compound zi...

Journal: :Drug metabolism and pharmacokinetics 2006
Susumu Nakade Shinya Ueda Tomoya Ohno Kazuki Nakayama Yasuyuki Miyata Eiji Yukawa Shun Higuchi

This study aimed to assess the steady-state pharmacokinetics of pranlukast, a leukotriene receptor antagonist, in children with allergic rhinitis and bronchial asthma, and to clarify factors affecting apparent clearance (CL/F). A total of 192 plasma samples were obtained from 98 children (rhinitis 64, asthma 13, complications 21), aged 3-14 years in 2 clinical trials. Plasma concentration of pr...

Journal: :Thorax 1986
J A Roberts I W Rodger N C Thomson

Leukotriene D4 (LTD4) may be an important mediator in asthma. The effect of verapamil and sodium cromoglycate on LTD4 induced bronchoconstriction has been examined in seven patients with asthma. The bronchoconstrictor response to increasing concentrations of inhaled LTD4 (0.0032-50 micrograms/ml) was assessed by measuring changes in FEV1, specific airways conductance, and flow rate at 30% of vi...

Journal: :BMJ 1999
C G Löfdahl T F Reiss J A Leff E Israel M J Noonan A F Finn B C Seidenberg T Capizzi S Kundu P Godard

OBJECTIVE To determine the ability of montelukast, a leukotriene receptor antagonist, to allow tapering of inhaled corticosteroids in clinically stable asthmatic patients. DESIGN Double blind, randomised, placebo controlled, parallel group study. After a single blind placebo run in period, during which (at most) two inhaled corticosteroids dose decreases occurred, qualifying, clinically stabl...

2016
Lorraine Burke Clare T. Butler Adrian Murphy Bruce Moran William M. Gallagher Jacintha O'Sullivan Breandán N. Kennedy

Colorectal cancer is the third most common cancer worldwide and is associated with significant morbidity and mortality. Current pharmacotherapy options include cytotoxic chemotherapy, anti-VEGF, and anti-EGFR targeting drugs, but these are limited by toxic side effects, limited responses and ultimately resistance. Cysteinyl leukotriene (CysLT) signaling regulates intestinal homeostasis with mou...

Journal: :The European respiratory journal 2002
M Romagnoli I Vachier P Tarodo de la Fuente H Meziane C Chavis J Bousquet P Godard P Chanez

Despite full effective treatment, asthmatic patients often present with poorly controlled asthma. Airway eosinophilia is associated with asthma, but its relationship with asthma control is still undetermined. To investigate the relationship between airway eosinophilia and asthma control, cellular and biochemical markers of airway inflammation were measured in 19 subjects with poorly controlled ...

Journal: :Blood 2012
Tanya M Laidlaw Molly S Kidder Neil Bhattacharyya Wei Xing Shiliang Shen Ginger L Milne Mariana C Castells Heng Chhay Joshua A Boyce

Cysteinyl leukotriene (cysLT) overproduction is a hallmark of aspirin-exacerbated respiratory disease (AERD), but its mechanism is poorly understood. Because adherent platelets can convert the leukocyte-derived precursor leukotriene (LT)A(4) to LTC(4), the parent cysLT, through the terminal enzyme LTC(4) synthase, we investigated the contribution of platelet-dependent transcellular cysLT produc...

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