visceral leishmaniasis or kala azar is endemic in certain regions of india. in endemic areas, the con-stellation of fever, progressive weight loss, weakness, pronounced splenomegaly, anemia, leukopenia, and hypergammaglobulinemia is highly suggestive of visceral leishmaniasis. demonstration of the parasite in liver, splenic or bone marrow aspirates is confirmatory. we present a case in which le...

Abstract Background We evaluated dengue presentation by age, the performance of 2015 PAHO case criteria in identifying cases, and variables to improve specificity. Methods Patients with fever ≤7 days (n = 10,408) were recruited from two emergency departments May 2012–December 2015. Serum samples tested for dengue, chikungunya, nasopharyngeal swabs respiratory viruses. Smoothing splines assessed...

WS1279, a new lipopeptide isolated from the fermentation broth of Streptomyces willmorei No. 1279, stimulated the proliferation of mouse bone marrow cells in vitro and accelerated the recovery of granulocyte counts in bone marrow from leukopenia induced by mitomycin C (MMC) in mice. The glycerylcysteine moiety of WS1279 is necessary and the lipid peptide structure is required for manifestation ...

The decision to operate for abdominal pain in patients with leukopenia can be exceedingly difficult. Surgical exploration may be the only effective way to differentiate acute appendicitis from other causes, but it involves considerable risk of infectious complications due to immunosuppression. Leukemic patients, who presented significant RLQ pain, had been indicated for operation, despite havin...

Presented 3 months after transplantation with history of febrile illness myalgia, arthralgia, thrombocytopenia, leukopenia. His low platelet and WBC counts were initially attributed to hypersplenism. Dengue was diagnosed using NS1antigen test he managed conservatively as for dengue fever. He recovered well his graft is functioning till last follow up.

Americans spend between $3.5 and $5 billion annually on herbal treatments, and nearly 50 million individuals currently report use of botanical supplements. With so many herbal products on the market, it is imperative that physicians thoroughly question patients with regard to supplement use. Physicians must understand the benefits and risks associated with medicinal herbs and counsel patients a...

A 58 year old woman developed systemic symptoms, interstitial lung disease, splenomegaly, leukopenia and anti-histone and anti-nuclear antibodies (ANA), while treated with hydralazine for hypertension. Five months after presentation she was admitted with high fever, skin rash and atypical lymphocytosis due to acute cytomegalovirus (CMV) infection. Worsening leukopenia and increased ANA were fou...

Carbamazepine (CBZ) is being prescribed more frequently for treatment of children and adults with generalized tonicclonic and partial complex seizures. Early reports of aplastic anemia in elderly patients treated with this drug led to concern about its potential hematological toxicity. A variety of other hematological abnormalities have also been described in association with CBZ therapy, inclu...