نتایج جستجو برای: leukemia cells
تعداد نتایج: 1520577 فیلتر نتایج به سال:
Leukemia inhibitory factor (LIF), a member of the IL-6 cytokine family, is highly expressed throughout body in multiple tissues and cell types. LIF primarily known to induce differentiation myeloid leukemia cells, but recent studies show that has many other functions, including playing roles cancer normal physiology. expression linked cellular proliferation, metastasis, inflammation, chemoresis...
Acute lymphoblastic leukemia (ALL) is the most common type of in children, comprising 75–85% cases. Aggressive treatment leukemias includes chemotherapy and antibiotics that often disrupt host microbiota. Additionally, gut microbiota may play a role development progression acute leukemia. Prebiotics, probiotics, postbiotics are considered beneficial to health. The prebiotics not well understood...
Early T precursor acute lymphoblastic leukemia (ETP ALL) is rare and has a characteristic phenotype. Mixed phenotype (MPAL), as per World Health Organization, needs to have two different lineages. On cytochemistry, myeloid lineage designated by more than 3% blast cells positivity for cytochemical myeloperoxidase (MPO). Flow cytometric analysis of MPO an arbitrary cutoff 10% been described in th...
Background:Brain and Acute Leukemia Cytoplasmic (BAALC) is a gene which its expression is confined to progenitor cells; therefore, no expression has been illustrated in mature cells of bone marrow or white blood cells (WBC). In addition, high BAALC expression is associated with poor prognosis in Acute Myeloid Leukemia (AML) individuals and is considered as an important risk factor in Cyto...
Treatment of human promonocytic leukemic cell line U937 with mild hyperthermia in the temperature range of 40-43°C resulted in differentiation of these cells into monocyte/macrophage-like cells in a heat dose and time dependent manner. This process was accompanied by marked morphological, functional and proliferational changes. U937 cells which normally grow in supension in the logarithmic...
methods s. cerevisiae was cultured and then disrupted by sonication. after centrifugation, the harvested supernatant was considered to be a cytoplasmic extract. the protein concentration was determined by the biuret method and the extract was diluted to concentrations of 500, 1000, and 2000 µg protein/ml. the frequencies of apoptosis and necrosis were assessed in extract-treated k562 cells by e...
T cells that recognize self-lipids presented by CD1c are frequent in the peripheral blood of healthy individuals and kill transformed hematopoietic cells, but little is known about their antigen specificity and potential antileukemia effects. We report that CD1c self-reactive T cells recognize a novel class of self-lipids, identified as methyl-lysophosphatidic acids (mLPAs), which are accumulat...
Ouabain has shown powerful anti-proliferation activities in various cancers, but its effect on imatinibresistant chronic myeloid leukemia and toxicity normal mice not been investigated. Cell Counting Kit-8 assay was used to detect cytotoxicity reversal of ouabain with different concentration (0.01 μM, 0.1 1.0 10 μM) drug resistance imatinib-resistant cell line (K562/G01 line). Flow cytometry th...
Background: Leukemia remains a global health challenge, requiring the exploration of alternative therapies with reduced side effects. Probiotics, particularly Lactobacillus species, have gained attention because their potential anticancer properties. This study investigated and cytotoxic effects postbiotic mediators (PMs) derived from rhamnosus GG (LGG) reuteri (LR) on acute lymphoblastic leuke...
nitric oxide (no) is a molecule required for many physiological functions, produced from l-arginine by no synthases (nos). it is a free radical, producing many reactive intermediates that account for its bioactivity. sustained induction of the inducible form of nos (inos) in chronic inflammation may be mutagenic, through no-mediated dna damage or hindrance to dna repair, and thus potentially ca...
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