نتایج جستجو برای: leukaemia

تعداد نتایج: 12087  

Journal: :British medical journal 1968
F W Gunz G F Spears

The distribution of leukaemia in time and space was examined by tracing the date of onset and the place of residence in all cases of childhood leukaemia and of acute leukaemia in adults, totalling 1,003 cases, which occurred in New Zealand during the 12 years from 1953 to 1964.Significant seasonal variations in the onset were found in adults but not in children. Time-space clustering did not oc...

2015
Vasundhara Sharma Sonu Elsa Jacob Praveen Kumar Sharma

Leukaemia is a cancer of blood that causes more deaths than any other cancer. Presently, the diagnosis of blood samples is done through visual examination by doctors. For proper and efficient treatment of leukaemia it is essential to detect it in early stage and proceed with the monitoring and evaluation. Till date many research have been done to design an automated system for detection of leuk...

Journal: :Postgraduate medical journal 1993
P N Soni

A 12 year old boy presenting with hypercalcaemia (calcium 3.25 mmol/l) and osteopaenia with multiple osteolytic lesions was found to have acute lymphoblastic leukaemia without lymph-adenopathy or organomegaly. Hypercalcaemia is a rare feature of acute leukaemia, but the patients previously described all show very similar characteristics, which were highlighted in this patient. These include age...

Journal: :Radiation protection dosimetry 2002
I Schmitz-Feuerhake H von Boetticher B Dannheim K Götz A Heimers W Hoffmann H Schröder

Only multiple X ray diagnostics could be identified as a common risk factor in a leukaemia cluster that appeared between 1985-1989 in the municipality of Sittensen in northern Germany. In order to judge if the effect could be explained by irradiation dose, estimates were done in two of the leukaemia cases and seven former patients of a practice where some of the leukaemia cases had been treated...

Journal: :Journal of epidemiology and community health 1984
E G Knox T Marshall R Barling

Data from the United Kingdom on childhood leukaemia and childhood cancer in twins and from the United States on leukaemia in twins are analysed by a new method. The method distinguishes determinants occurring before the stage of pregnancy corresponding with the cleavage of MZ pairs, from determinants occurring after this point. It derives estimates of the frequencies of each class of determinan...

Journal: :Lancet 2008
Dani Bercovich Ithamar Ganmore Linda M Scott Gilad Wainreb Yehudit Birger Arava Elimelech Chen Shochat Giovanni Cazzaniga Andrea Biondi Giuseppe Basso Gunnar Cario Martin Schrappe Martin Stanulla Sabine Strehl Oskar A Haas Georg Mann Vera Binder Arndt Borkhardt Helena Kempski Jan Trka Bella Bielorei Smadar Avigad Batia Stark Owen Smith Nicole Dastugue Jean-Pierre Bourquin Nir Ben Tal Anthony R Green Shai Izraeli

BACKGROUND Children with Down's syndrome have a greatly increased risk of acute megakaryoblastic and acute lymphoblastic leukaemias. Acute megakaryoblastic leukaemia in Down's syndrome is characterised by a somatic mutation in GATA1. Constitutive activation of the JAK/STAT (Janus kinase and signal transducer and activator of transcription) pathway occurs in several haematopoietic malignant dise...

Journal: :BMJ 1992
G M Kendall C R Muirhead B H MacGibbon J A O'Hagan A J Conquest A A Goodill B K Butland T P Fell D A Jackson M A Webb

OBJECTIVE To study cause specific mortality of radiation workers with particular reference to associations between fatal neoplasms and level of exposure to radiation. DESIGN Cohort study. SETTING United Kingdom. SUBJECTS 95,217 radiation workers at major sites of the nuclear industry. MAIN OUTCOME MEASURE Cause of death. RESULTS Most standardised mortality ratios were below 100: 83 un...

Journal: :Dose-response : a publication of International Hormesis Society 2014
Marek K Janiak

A few reports of increased numbers of leukaemia cases (clusters) in children living in the vicinity of nuclear power plants (NPP) and other nuclear installations have triggered a heated debate over the possible causes of the disease. In this review the most important cases of childhood leukaemia clusters around NPPs are described and analyzed with special emphasis on the relationship between th...

Journal: :Lancet 2010
Utz Krug Christoph Röllig Anja Koschmieder Achim Heinecke Maria Cristina Sauerland Markus Schaich Christian Thiede Michael Kramer Jan Braess Karsten Spiekermann Torsten Haferlach Claudia Haferlach Steffen Koschmieder Christian Rohde Hubert Serve Bernhard Wörmann Wolfgang Hiddemann Gerhard Ehninger Wolfgang E Berdel Thomas Büchner Carsten Müller-Tidow

BACKGROUND About 50% of patients (age ≥60 years) who have acute myeloid leukaemia and are otherwise medically healthy (ie, able to undergo intensive chemotherapy) achieve a complete remission (CR) after intensive chemotherapy, but with a substantially increased risk of early death (ED) compared with younger patients. We verified the association of standard clinical and laboratory variables with...

Journal: :The Journal of general virology 1986
M Wleklik S B Levy M Luczak V A Najjar

A significant decrease in mortality was observed when 25 micrograms of the tetrapeptide tuftsin was given to DBA/2J mice 5 days before infection with Friend leukaemia virus (FLV). The same effect was observed when tuftsin was given 5 days before and twice a week for 3 weeks after FLV infection. No effect was observed when the same amount of tuftsin was given 1 day before infection. A 5 microgra...

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