The participation of renal metallothionein (MT) in the toxicity and antitumor activity of cis-diamminedichloroplatinum(II) (cis-DDP) in male mice was examined. Preinduction of MT in the kidney by the s.c. administration of bismuth compounds decreased the lethality and renal and gastrointestinal toxicity caused by a single s.c. injection of cis-DDP. In the present study a correlation between the...

conclusions the present study provides the first experimental evidence in support of dexmedetomidine treatment for cocaine-induced seizures. premedication with dexmedetomidine reduces seizure activity in a mouse model of acute cocaine toxicity. in addition, while dexmedetomidine may be effective, moxonidine and alpha-methyldopa did not effectively prevent cocaine-induced lethality. results the ...

the potato tuber moth (ptm), phthorimaea operculella (zeller) is one of the important pests of potato in tropical regions. in this research, the toxicity of two insecticides, abamectin and deltamethrin on p. operculella was studied at 26 ± 1 c°, 65 ± 5% rh and photoperiod of 16:8 h (l: d). the concentrations were determined by preliminary dose setting experiments. distilled water was used as co...

Copyright © 2012 Massachusetts Medical Society. Opioid analgesic overdose is a preventable and potentially lethal condition that results from prescribing practices, inadequate understanding on the patient’s part of the risks of medication misuse, errors in drug administration, and pharmaceutical abuse.1,2 Three features are key to an understanding of opioid analgesic toxicity. First, opioid ana...

Honeybee, Apis mellifera, is one of the most important pollinators in the world. Since pesticides have been used widely, honeybees are unavoidable at risk exposing to various contaminated sources of residual pesticides while they are engaging foraging activities in collecting nectar and pollens. The effects of various levels of sub-lethal dosages of insecticides on the biology, development and ...

People not only inhale airborne contaminants but also absorb them through the skin. Both routes can set off localized toxic reactions or damage internal organs such as the liver, kidney, and brain. Conventional tests of the toxicity of gases and vapors, in which laboratory animals are exposed to lethal or sub-lethal doses of chemicals, have been criticized as expensive, unethical, inhumane, and...

Lethal effects of zinc sulphate (ZnSO4.H2O), a widespread environmental pollutant was evaluated following exposure at different concentrations of the toxicant to Tilapia species, Oreochromis niloticus based on toxicity index of 96 hrs LC50 values. The obtained results were analyzed by the Finney’s Probit Analysis LC50 Method and 96 hrs LC50 value for Oreochromis niloticus was found to be 72.431...

Escherichia coli O89 lipopolysaccharide (LPS) was treated with different doses of gamma irradiation (5, 10, 15, and 20 Mrad). Various biological activities such as lethal effect, decrease in arterial blood pressure in dogs, and interaction with the complement system were determined for the parent and irradiated preparations. Irradiation of LPS significantly and in a dose-dependent manner decrea...

Human toxicity NaF and ionic fluoride, later only fluoride (1 mg of NaF corresponds to 0.45 mg of fluoride, also called “fluor”) are toxic for humans at the higher doses; gastrointestinal symptoms have occurred following fluoride ingestion from 3 to 5 mg/kg of body weight. The lethal doses of NaF in adults range from 70 to 140 mg/kg, which corresponds to 31.5-63 mg fluoride/kg of body weight [2...