نتایج جستجو برای: lethal

تعداد نتایج: 43991  

2001
Joseph Mastropaolo

The foundation of evolution is abiogenesis, life spontaneously generated from nonlife. The superstructure placed upon that foundation is monogenesis, myriad spontaneously generated structures to produce every kind of simple life form then by countless spontaneous generations every kind of complex life form. The other “definitions” of evolution are change over time, common descent and natural se...

2010

Designed to provide all those interested in Africa with quick reference and a reliable set of data to monitor development programs and aid flows in the region, this is an invaluable reference tool for analysts and policy makers who want a better understanding of the economic and social developments occurring in Africa. tBasic indicators tNational and fiscal accounts tExternal accounts and excha...

Journal: :Trends in genetics : TIG 2003
Daniel L Halligan Peter D Keightley

Knowledge of the frequency of lethal mutant alleles in a population is important for our understanding of population genetics and evolution, and yet there have been few attempts to measure their number in wild populations. A new study has revealed unexpectedly low numbers of segregating lethal alleles in two species of fish. More experiments are needed, however, to know whether this result is g...

Freshwater fish Cirrhinus mrigala were exposed to lethal concentration (5 mg/L) for 1,2,3,4 days and sublethal concentration (1 mg/L) for 1,7,14,21 days of cypermethrin to examine the enzymes activity, in functionally three different tissues namely, gill, liver and muscle. Activities of Aspartate aminotransferase (AAT), Alanine aminotransferase (AlAT) and Glutamate dehydrogenase (GDH) increased...

2016
Rachel S. Kelly Jennifer A. Sinnott Jennifer R. Rider Ericka M. Ebot Travis Gerke Michaela Bowden Andreas Pettersson Massimo Loda Howard D. Sesso Philip W. Kantoff Neil E. Martin Edward L. Giovannucci Svitlana Tyekucheva Matthew Vander Heiden Lorelei A. Mucci

BACKGROUND Understanding the biologic mechanisms underlying the development of lethal prostate cancer is critical for improved therapeutic and prevention strategies. In this study we explored the role of tumor metabolism in prostate cancer progression using mRNA expression profiling of seven metabolic pathways; fatty acid metabolism, glycolysis/gluconeogenesis, oxidative phosphorylation, pentos...

Journal: :Infection and immunity 2012
Marybeth Langer Elizabeth Stewart Duggan John Leland Booth Vineet Indrajit Patel Ryan A Zander Robert Silasi-Mansat Vijay Ramani Tibor Zoltan Veres Frauke Prenzler Katherina Sewald Daniel M Williams Kenneth Mark Coggeshall Shanjana Awasthi Florea Lupu Dennis Burian Jimmy Dale Ballard Armin Braun Jordan Patrick Metcalf

The lung is the site of entry for Bacillus anthracis in inhalation anthrax, the deadliest form of the disease. Bacillus anthracis produces virulence toxins required for disease. Alveolar macrophages were considered the primary target of the Bacillus anthracis virulence factor lethal toxin because lethal toxin inhibits mouse macrophages through cleavage of MEK signaling pathway components, but w...

Journal: : 2021

The median lethal dose (LD 50 ) and low 10 are calculated in acute toxicity studies, as well during specific activity assessment of some medicines. aim the study was to develop a procedure for using CombiStats calculate LD . authors proposed step-by-step algorithm processing bioassay results biometric software (median effective determination model, probit analysis) with conversion doses simple ...

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