T he Lepr/Lepr mouse is an autosomal recessive model of extreme obesity that phenotypically appears very similar to the Lepr/Lepr mouse, in which the leptin protein is absent (1). However, in the Lepr/Lepr mouse, the leptin protein is structurally normal (1). Leptin is ineffectual when injected into Lepr/Lepr mice, indicating that they are resistant to the action of this hormone (1). Recently, ...

Association of rs1800624 Polymorphism in Receptor for Advanced Glycation End Products Gene Promoter with the Risk Diabetic Nephropathy

Leptin has been suggested to play a role in the etiology of Adolescent Idiopathic Scoliosis (AIS), however, the leptin levels in AIS girls are still a discrepancy, and no in vitro study of leptin in AIS is reported. We took a series of case-control studies, trying to understand whether Leptin gene polymorphisms are involved in the etiology of the AIS or the change in leptin level is a secondary...

Control of processes responsible for food intake and regulation of energy homeostasis during pregnancy is crucial for mother as well as for fetus development. Leptin is one of the main hormonal factors involved in regulation these processes in organisms. During pregnancy leptin regulates mother's energy balance and may also affect fetus growth and development, particularly via receptors in hypo...

Receptor subunits for the neurocytokine ciliary neurotrophic factor (CNTF) share sequence similarity with the receptor for leptin, an adipocyte-derived cytokine involved in body weight homeostasis. We report here that CNTF and leptin activate a similar pattern of STAT factors in neuronal cells, and that mRNAs for CNTF receptor subunits, similarly to the mRNA of leptin receptor, are localized in...

Variants in leptin gene (LEP) have been implicated in the pathogenesis of obesity. The relationship between LEP G-2548A polymorphism and obesity-related traits was evaluated in a sample of Brazilian women (n = 228) who were randomly selected from two clinical centers in Sao Paulo city. Blood samples were collected for DNA extraction, plasma leptin and serum lipids measurements. LEP G-2548A geno...

background one-third of the world’s population is infected with mycobacterium tuberculosis. investigation of toll-like receptors (tlrs) has revealed new information regarding the immunopathogenesis of this disease. toll-like receptors can recognize various ligands with a lipoprotein structure in the bacilli. toll-like receptor 2 and tlr-4 have been identified in association with tuberculosis in...

background uterine leiomyoma (uls) is the most common gynecological tumor and a significant health concern for many women .the interleukin-1 receptor antagonist (il-1ra) is a naturally occurring cytokine inhibiting interleukin- 1 (il-1) activity by binding to the il-1 receptors without signal transduction. objectives the aim of this study was to investigate the association between interleukin-1...