PURPOSE To evaluate the maximum tolerated dose (MTD), dose-limiting toxicities (DLT), and pharmacokinetics of liposome-entrapped paclitaxel easy-to-use (LEP-ETU) and to characterize the relationship between LEP-ETU concentrations and the time course of neutropenia in cancer patients. EXPERIMENTAL DESIGN LEP-ETU was administered to 88 patients and 63 were evaluable for pharmacokinetic/pharmaco...

The article presents the results of complex research that continues previous work aimed at determining polymorphism CSN2, PRL, LEP, and TNF-α loci analyzing productivity dairy cattle with different genotypes for these loci. goal is to analyze selection populations cows based on typing individuals allelic variants loci, which are associated economically valuable traits but not directly evaluated...

The status of the LEP 1 results, the LEP 2 perspectives and some recent developments in high energy physics at e + e − machines are briefly discussed.

After years of efforts to push the LEP performance to, and indeed beyond, the limits of what had been believed possible, hints of a signal of a Higgs boson at 115GeV/c appeared in June 2000, were confirmed in September, and confirmed again in November. Spending an additional six-month period with LEP would have given the unambiguous opportunity of a fundamental discovery. Instead, this possibil...

BACKGROUND AND OBJECTIVE Health providers need reliable estimates of the number of families with limited English proficiency (LEP) to assess language need and language service provision. Hospitals often lack reliable language screening tools and fail to provide interpretation for LEP families. The objective of this study was to develop a simple audit tool to more accurately identify LEP patient...

BACKGROUND Approximately 3.5 million U.S. schoolchildren are limited in English proficiency (LEP). Disparities in children's health and health care are associated with both LEP and speaking a language other than English at home, but prior research has not examined which of these two measures of language barriers is most useful in examining health care disparities. OBJECTIVES Our objectives we...

BACKGROUND Preclinical studies comparing paclitaxel formulated with polyethoxylated castor oil with the sonicated formulation of liposome-entrapped paclitaxel (LEP) have demonstrated that LEP was associated with reduced toxicity while maintaining similar efficacy. Preliminary studies on the pharmacokinetics in patients support earlier preclinical data, which suggested that the LEP Easy-to-Use (...

Leprosy is a chronic infectious disease that may present different clinical forms according to the immune response of the host. Levels of IFN-γ are significantly raised in paucibacillary tuberculoid (T-lep) when compared with multibacillary lepromatous (L-lep) patients. IFN-γ primes macrophages for inflammatory activation and induces the autophagy antimicrobial mechanism. The involvement of aut...