The cataractogenic potential of the thiazolidinedione ciglitazone (CIG) was investigated in vivo and in vitro. In the rat, CIG caused a dose-dependent (30-300 mg/kg/day) increase in incidence and severity of nuclear cataract formation during a 3-month nonclinical safety assessment study. Potential mechanisms of toxicity were surveyed using whole rat lens explants exposed to CIG with or without ...

OBJECTIVES The aim of this study was to determine ultraviolet (UV) action spectra for cell killing of primary porcine lens epithelial cells (LECs) that can be used to establish guidelines for evaluation of the hazard of cataract due to UV exposure in the workplace. METHODS Primary porcine LECs were exposed to different doses (radiant exposure) of UV at 17 different wavelengths from 235 nm to ...

Recently, substances possessing antioxidant can prevent cataractogenesis of diabetic cataract. Therefore, this study was carried out to determine the anticataract effect of Zea mays L. (purple waxy corn), a flavonoids rich plant, in experimental diabetic cataract. Enucleated rat lenses were incubated in artificial aqueous humor containing 55 mM glucose with various concentrations of Zea mays L....

To examine the mechanism of ocular axial elongation in myopia, guinea pigs (age: 2-3weeks) which either underwent unilateral or bilateral lens-induced myopization (group 1) or which were primarily myopic at baseline (group 2) received unilateral intraocular injections of amphiregulin antibody (doses: 5, 10, or 15μg) three times in intervals of 9days. A third group of emmetropic guinea pigs got ...

The International Commission on Radiological Protection (ICRP) statement on tissue reactions, issued by the Commission in April 2011, reviewed epidemiological evidence and suggested that there are some tissue reactions where threshold doses are or may be lower than those previously considered. For the lens of the eye, the threshold is now considered to be 0.5 Gy. The absorbed dose threshold for...

BACKGROUND The use of ionizing radiation has led to advances in medical diagnosis and treatment. OBJECTIVES The purpose of this study was to determine the risk of radiation cataractogenesis in the interventionists and staff performing various procedures in different interventional laboratories. PATIENTS AND METHODS This cohort study included 81 interventional cardiology staff. According to ...

purpose : to compare visual outcome of aspheric and spheric intraocular lenses (iols) implantation in patients with age-related cataract in terms of visual acuity (va), contrast sensitivity (cs) and spherical aberration methods : in this prospective randomized interventional study, 59 consecutive cases of senile cataract who had been admitted for cataract surgery to farabi eye hospital, tehran,...

In the present study, the lenses and ciliary bodies of 20 ostrich eyes were studied macroscopically and microscopically. The histological slides were studied after staining by hematoxylin and eosin, Verhoeff, Van Gieson, and periodic acid-Schiff (PAS). Posterior surface of lens was more convex than its anterior surface. The average lens diameter and thickness were respectively measured as 1.43 ...

BACKGROUND: The widespread use of radiation sources in medical practice (cardioendovascular surgery, endoscopy, traumatology, urology, neurosurgery, dentistry, radioisotope diagnostics departments) leads to irradiation the lens eye and skin hands with low-intensity scattered radiation. introduction new recommendations by IAEA reduce limit annual equivalent dose (20 mSv), has led incorrectness a...