one of the common chronic inflammatory skin diseases is acne vulgaris that affects up to 80% of a teen-age population. the progress of acne lesions is due to colonization of propionibacterium acnes (p .acnes) in hair follicles. treatment of acne includes topical or systemic therapy or combination therapy, with a tendency to perform topical therapy in mild to moderate acne. nanoemulsions, small ...

Oxaliplatin (OXA) is a third-generation cisplatin analog that has been approved as first-line chemotherapy in combination with 5-fluorouracil (5-FU) for the treatment of resectable and advanced colorectal cancer. However, the therapeutic efficacy of oral OXA and 5-FU is limited by their low bioavailability due to poor membrane permeability. The aim of the present study was to develop an oral de...

PURPOSE Safe and effective lipid nanoemulsion (LNE) formulations for the antitumor delivery of doxorubicin is designed. METHODS LNEs composed of medium-chain triglyceride, soybean oil, lecithin, and doxorubicin are prepared by a solvent-diffusion method in an aqueous system. The effects of lipid material composition and polyethylene glycol (PEG)ylation on the size, drug encapsulation efficien...

When pure individual synthetic lecithins became available for study (Baer and Kates, 1949, 1950), there was immediate interest in their possible use in cardiolipin antigens as substitutes for Pangborn lecithin. Rosenberg (1949) reported briefly on synthetic L-c-(dipalmitoyl)-lecithin in antigens for the Hinton, Kline, Rein-Bossack, VDRL, and Kolmer tests. He found that replacement of Pangborn's...

Abstract This study investigated the effectiveness of foliar application sweet chestnut wood distillate on photosynthetic performance and growth lettuce ( Lactuca sativa L. cv ‘Canasta’), both alone in combination with soybean lecithin used as biosurfactant. Seedlings were treated a either mineral water (control), or 1:500 solutions 3% soy lecithin, plus lecithin. After 1 week, chlorophyll cont...

BACKGROUND Previous studies have shown that plasma and urinary free choline concentrations decrease significantly during a marathon, and that these decreases may be associated with decreased performance. OBJECTIVE In a pilot study, we sought to determine whether lecithin supplementation prior to a marathon would maintain plasma free and urinary choline concentrations and improve performance v...

Corresponding Author: Asha Patel, Anand Pharmacy College, Anand, 388001, Gujarat, India Email: [email protected] Abstract: In current study, a nanoemulsion as drug delivery system (NE) of spray dried Boswellia Serrata Extract (BSE) was developed and characterized to compare it in vitro/Ex vivo diffusion with reference formulation. Pseudo-ternary phase diagrams were constructed by phase di...

Lecithin or phospholipids is natural and widely used emulsifier. To improve its emulsifying properties, lecithin is modified by enzymatic hydrolysis using Phospholipase A1 (PLA1). PLA1 hydrolyzes at sn-1 position, that usually occupied by saturated fatty acids and more unsaturated fatty acid in lecithin is expected to increase hydrophilic properties. This study was aimed to investigate the hydr...

The solubilization of glucose and several related sugars in benzene solutions of rigorously purified phosphatidylcholine has been studied; the equilibrium degree of solubilization has been found to depend on the size of the sugar molecule relative to that of the lecithin micelle, and on the number and the acidity of its free hydroxyl groups. The uptake of glucose increased as the lecithin conce...