This paper discusses the mathematical framework for designing methods of large deformation matching (LDM) for image registration in computational anatomy. After reviewing the geometrical framework of LDM image registration methods, a theorem is proved showing that these methods may be designed by using the actions of diffeomorphisms on the image data structure to define their associated momentu...

The linear dynamic model (LDM), also known as the Kalman filter model, has been the subject of research in the engineering, control, and more recently, machine learning and speech technology communities. The Gaussian noise processes are usually assumed to have diagonal, or occasionally full, covariance matrices. A number of recent papers have considered modelling the precision rather than covar...

Metronomic chemotherapy is an emerging strategy offering a potentially less toxic yet effective treatment modality. We evaluated the efficacy and safety of low-dose metronomic (LDM) chemotherapy in relapsed or refractory non-Hodgkin lymphoma (NHL) by retrospectively reviewing the data of 16 NHL patients who were treated with oral cyclophosphamide plus methotrexate (CM) as LDM chemotherapy. The ...

BEL~M(A,Z) = a,A asA2’3aJ2/A”3 + a,A“‘* asym (N-Z)2/A (1) where N, Z and A are the neutron, proton and mass numbers; a,, a, and a, are the volume, surface and Coulomb terms in the liquid drop model. aPA-“* is the pairing energy. The last term in Eq. (l), asym (N-Z)‘/A, accounts for the symmetry energy which favors nuclei with equal number of protons and neutrons. In most parametrizations, asym ...

The development of (semi)-autonomous vehicles and communication between vehicles and infrastructure (V2X) will aid to improve road safety by identifying dangerous traffic scenes. A key to this is the Local Dynamic Map (LDM), which acts as an integration platform for static, semi-static, and dynamic information about traffic in a geographical context. At present, the LDM approach is purely datab...

After oral ingestion, Toxoplasma gondii crosses the intestinal epithelium, disseminates into the deep tissues, and traverses biological barriers such as the placenta and the blood-brain barrier to reach sites where it causes severe pathology. To examine the cellular basis of these processes, migration of T. gondii was studied in vitro using polarized host cell monolayers and extracellular matri...

We present recent developments towards building a speech synthesis system completely based on Linear Dynamical Models (LDMs). Specifically, we describe a decision tree-based context clustering approach to LDM-based speech synthesis and an algorithm for parameter generation using global variance with LDMs. In order to capture the speech dynamics, LDMs need coarser phoneme segmentation than the 5...

The success of cardiomyoplasty and other surgical procedures involving the redeployment of the latissimus dorsi muscle (LDM) depends crucially on preserving the long-term viability of the muscle graft. The need to sacrifice perforating arteries during mobilization renders the grafted muscle vulnerable to ischaemic damage when it is subjected to electrical stimulation, a problem that is not adeq...

The physiological, biochemical and functional differences between oxidative and glycolytic muscles play important roles in human metabolic health and in animal meat quality. To explore these differences, we determined the genome-wide landscape of DNA methylomes and their relationship with the mRNA and miRNA transcriptomes of the oxidative muscle psoas major (PMM) and the glycolytic muscle longi...

a r t i c l e i n f o a b s t r a c t At martian mid-to-high latitudes, the surfaces of potentially ice-rich features, including concentric crater fill, lobate debris aprons, and lineated valley fill, typically display a complex texture known as " brain terrain, " due to its resemblance to the complex patterns on brain surfaces. In order to determine the structure and developmental history of c...