نتایج جستجو برای: ldh
تعداد نتایج: 8813 فیلتر نتایج به سال:
Four pyridine nucleotide-linked dehydrogenases, glucose-6phosphate dehydrogenase (G6PDH),3 isocitric dehydrogenase (ICDH), lactic dehydrogenase (LDH), and malic dehydrogenase (MDH), and their isozymes have been studied in the normal virgin rat breast, in the breast of tumor-bearing rats, in the breast cancers themselves, and in these tissues following ovariectomy. Enzyme activity expressed per ...
Serum lactate dehydrogenase (LDH) level was estimated in 44 childhood (age range 1-15 years) acute lymphoblastic leukemia (ALL) on admission, day 14 and day 29 of induction. Another 25 children without ALL were included as control. On admission, the level of serum LDH was significantly high in ALL cases than control (p < 0.001). Total WBC count was significantly decreased along with serum LDH l...
In an attempt to clarify the mechanism of LDH protein reaction with FMN, amino acid residues in the protein moiety such as histidine, arginine, tyrosine and tryptophan were chemically modified so that their effects on LDH activity and FMN reaction could be investigated. Although it was recognized that histidine and arginine residues participate in the catalytic action, and that these residues e...
The lactate dehydrogenase-A (LDH-A) enzyme catalyzes the interconversion of pyruvate and lactate, is upregulated in human cancers, and is associated with aggressive tumor outcomes. Here we use an inducible murine model and demonstrate that inactivation of LDH-A in mouse models of NSCLC driven by oncogenic K-RAS or EGFR leads to decreased tumorigenesis and disease regression in established tumor...
Usefulness of lactate dehydrogenase and its isoenzymes as indicators of lung damage or inflammation.
This review describes the usefulness of monitoring the activity level of lactate dehydrogenase (LDH) and its isoenzyme pattern as indicators of pathological conditions in the lungs, such as cell damage or inflammation. Cytoplasmatic cellular enzymes, like LDH, in the extracellular space, although of no further metabolic function in this space, are still of benefit because they serve as indicato...
The serum of a patient with IgG1-lambda type M-proteinemia showed an abnormal isoenzyme pattern for lactate dehydrogenase (LDH, EC 1.1.1.27). By affinity chromatography, we showed that four isoenzymes (LDH2, LDH3, LDH4, and LDH5) were bound to the M-protein. This complex formation was not blocked by anti-idiotype antibody, even though the binding capacity of IgG was exclusively located in the F...
Background: To determine relationship between the levels of serum Lactate Dehydrogenase (LDH)on admission and prognosis of dengue fever. Methods: Patients (n=62) admitted with the diagnosis of dengue fever were included. On admission, serum LDH levels were measured in all patients and to find relationship we monitored all patients upto discharge. Monitoring was done for vitals, different blood ...
Lactate dehydrogenase A (LDH-A), which regulates glycolytic flux by catalyzing pyruvate to lactate in the cytoplasm, is believed to be one of the highly attractive therapeutic targets for cancers. Firstly, we detected the expression of LDH-A in gastric cancer (GC) cells. LDH-A inhibitor oxamate was then used to suppress the LDH-A activity in GC cells. Cell proliferation, lactic acid production,...
Lactate dehydrogenase (LDH) is commonly used in human cancer patients for prognostic purposes. Aim of this study was to determine the magnitude of serum LDH elevation in dogs with cancer compared with healthy dogs and dogs with non-neoplastic disease, and to verify whether it may support the diagnosis of specific malignancies. About 128 healthy dogs, 211 diseased dogs and 188 cancer dogs were e...
Populations of the teleost fish Fundulus heteroclitus are subjected to the clinical variation in environmental temperatures that occurs along the eastern seacoast of North America. In concordance with this change in temperature is the clinal variation in the enzyme concentration of the heart-type lactate dehydrogenase (LDH-B; E.C.1.1.1.27). Previously we have shown that the compensating change ...
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