نتایج جستجو برای: lc3

تعداد نتایج: 2730  

2018
Zheng Li Fubing Liu Liang Zhang Yuanwu Cao Yunchao Shao Xiaofeng Wang Xiaoxing Jiang Zixian Chen

This study is to reveal the characteristics of autophagy and the effect of neuroserpin (NSP) treatment on autophagy during the process of functional recovery following spinal cord injury (SCI). After the clip compress rat model of SCI had been made, autophagy‑associated proteins, including LC3‑II, beclin‑1 and p62, were evaluated at 2, 4, 24, 72 h, and 168 h in the experimental group, and the s...

2011
Laura Berliocchi Rossella Russo Maria Maiarù Alessandra Levato Giacinto Bagetta Maria Tiziana Corasaniti

Autophagy is an intracellular membrane trafficking pathway controlling the delivery of cytoplasmic material to the lysosomes for degradation. It plays an important role in cell homeostasis in both normal settings and abnormal, stressful conditions. It is now recognised that an imbalance in the autophagic process can impact basal cell functions and this has recently been implicated in several hu...

Journal: :Rinsho shinkeigaku = Clinical neurology 2014
Koichi Wakabayashi Kunikazu Tanji

Macroautophagy is a dynamic process whereby cytoplasmic molecules are sequestered within autophagosomes. There exist two groups of mammalian autophagy-related gene (Atg) 8 homologues (LC3 and GABARAPs), which play essential role in autophagosomal formation. We determined whether Atg8 homologues are affected in Lewy body disease (LBD) and multiple system atrophy (MSA). The level of LC3 was incre...

2018
Naser Jafargholizadeh Seyed Jalal Zargar Younes Aftabi

Objectives Cucurbitacins exhibit a range of anti-cancer functions. We investigated the effects of cucurbitacins D, E, and I purified from Ecballium elaterium (L.) A. Rich fruits on some apoptotic and autophagy genes in human gastric cancer cell line AGS. Materials and Methods Using quantitative reverse transcription PCR (qRT-PCR), the expression of LC3, VEGF, BAX, caspase-3, and c-MYC genes w...

Journal: :Journal of virology 2007
Matthew P Taylor Karla Kirkegaard

Poliovirus infection remodels intracellular membranes, creating a large number of membranous vesicles on which viral RNA replication occurs. Poliovirus-induced vesicles display hallmarks of cellular autophagosomes, including delimiting double membranes surrounding the cytosolic lumen, acquisition of the endosomal marker LAMP-1, and recruitment of the 18-kDa host protein LC3. Autophagy results i...

2013
Annie Hiniker Brianne H Daniels Han S Lee Marta Margeta

BACKGROUND Inclusion body myositis (IBM) is a slowly progressive inflammatory myopathy of the elderly that does not show significant clinical improvement in response to steroid therapy. Distinguishing IBM from polymyositis (PM) is clinically important since PM is steroid-responsive; however, the two conditions can show substantial histologic overlap. RESULTS We performed quantitative immunohi...

2013
Hye-Eun Han Tae-Kyung Kim Hyung-Jin Son Woo Jin Park Pyung-Lim Han

Microglia play a role in maintaining and resolving brain tissue homeostasis. In pathological conditions, microglia release pro-inflammatory cytokines and cytotoxic factors, which aggravate the progression of neurodegenerative diseases. Autophagy pathway might be involved in the production of pro-inflammatory cytokines and cytotoxic factors in microglia, though details of the mechanism remain la...

Journal: :Journal of neuropathology and experimental neurology 2011
Shinji Higashi Darren J Moore Michiko Minegishi Koji Kasanuki Hiroshige Fujishiro Tomohiro Kabuta Takashi Togo Omi Katsuse Hirotake Uchikado Yoshiko Furukawa Hiroaki Hino Kenji Kosaka Kiyoshi Sato Heii Arai Keiji Wada Eizo Iseki

There is emerging evidence implicating a role for the autophagy-lysosome pathway in the pathogenesis of Lewy body disease. We investigated potential neuropathologic and biochemical alterations of autophagy-lysosome pathway-related proteins in the brains of patients with dementia with Lewy bodies (DLB), Alzheimer disease (AD), and control subjects using antibodies against Ras-related protein Rab...

Journal: :Cell host & microbe 2014
Christian Münz

Autophagy, a cellular degradation pathway, can restrict or assist viral replication. In this issue of Cell Host & Microbe, Beale et al. (2014) report that the influenza virus matrix protein 2 binds to the essential autophagy protein LC3 to presumably transport LC3-conjugated membranes to the cell surface for budding of stable viruses.

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