in this paper, the conjugate gradient method coupled with adjoint problem is used in order to solve the inverse heat conduction problem and estimation of the time- dependent heat flux using the temperature distribution at a point in a three layer system with none homogeneous boundary conditions. also, the effect of noisy data on final solution is studied. for solving this problem the general co...

Department of Physics of Molecular Imaging Systems, Institute for Experimental Molecular Imaging, RWTH Aachen University, Aachen, Germany Conventional positioning algorithms in PET assume a photon interaction and complete energy deposition in one detector element (single-hit). However, there is a high probability that a photon interacts within a crystal element via Compton scattering but is abs...

Two different approaches are applied to quantify mixing in a shallow water model of the stratosphere. These are modified Lagrangian mean (MLM) theory and a technique referred to as ‘‘reverse domain filling with local gradient reversal’’ (RDF-LGR). The latter is similar to a previously existing technique using contour advection and contour surgery. It is first proved that in an inviscid shallow ...

Mixed models have become the tool of choice for genetic association studies; however, standard mixed model methods may be poorly calibrated or underpowered under family sampling bias and/or case-control ascertainment. Previously, we introduced a liability threshold-based mixed model association statistic (LTMLM) to address case-control ascertainment in unrelated samples. Here, we consider famil...

Computational vision algorithms are often developed in a Bayesian framework. Two estimators are commonly used: maximum a posteriori (MAP), and minimum mean squared error (MMSE). We argue that neither is appropriate for perception problems. The MAP estimator makes insufficient use of structure in the posterior probability. The squared error penalty of the MMSE estimator does not reflect typical ...

two-layer metallic sheets have wide applications in aerospace, marine, automotive and domestic industries due to their superlative characteristics. in this paper, the formability of two-layer sheet is investigated through analytical, experimental and numerical approaches. an analytical model is developed based on marciniak-kuczynski method associated hill’s non-quadratic yield criterion. formin...

Triclocarban (3,4,4'-trichlorocarbanilide; TCC) is widely used as an antibacterial in bar soaps. During use of these soaps, a significant portion of TCC is absorbed by humans. For the elimination from the body, glucuronidation plays a key role in both biliary and renal clearance. To investigate this metabolic pathway, we performed microsomal incubations of TCC and its hydroxylated metabolites 2...

Radiative multipole moments of scalar, electromagnetic, and linearized gravitational fields in Schwarzschild spacetime are computed to third order in v in a weak-field, slow-motion approximation, where v is a characteristic velocity associated with the motion of the source. These moments are defined for all three types of radiation by relations of the form Ψ(t, ~ x) = r ∑ lm Mlm(u)Ylm(θ, φ), wh...

Abstract The adoption of genomics by healthcare systems is crucial to fulfill the potential Personalised Medicine for patients and citizens. This a challenging undertaking, requires from extensive adjustments in key issues, such as technical infrastructure, health professional competences or ethical legal frameworks. starting point an effective identification specific challenges barriers develo...