The authors describe a patient who presented an association of hairy cell leukemia (HCL) and large granular lymphocyte (LGL) leukemia. An eventual relationship between these two rare entities is analyzed. Hairy cells (HCs) were present in the blood, bone marrow, and spleen. An excess of LGLs was found only in the blood and bone marrow. After splenectomy the patient received an alpha 2-interfero...

To study the cellular structures involved in NK and lymphokine-activated killer (LAK) cell function, we have produced a panel of mAbs that modulate the cytolytic function of a population of cells with LAK activity that derive from large granular lymphocyte (LGL)/NK cells (adherent LAK [A-LAK] cells). In this report, we describe an mAb (3.2.3; IgG1k) that recognizes a triggering structure that i...

CD4+ CD8+ cells are present during T cell differentiation in the thymus. Less than 2% of normal T cells that coexpress CD4 and CD8 also are released in the circulation and are present in the peripheral blood. In this study, nine individuals are described that manifested persistent expansions (11% to 43%) of circulating CD4+ CD8+ T cells that in three cases had large granular lymphocyte (LGL) mo...

T7 lymphocytes are those lymphocytes that express receptors for both the Fc portion of lgG and sheep erythrocytes. A very high proportion of normal T. lymphocytes are large granular lymphocytes (LGL). the cell responsible for most, if not all. natural killer (NK) and antibody-dependent cellmediated cytotoxicity (ADCC) in humans. rats. and mice. In general. these cells are large lymphocytes with...

Journal Compilation © 2012 Acta Dermato-Venereologica. ISSN 0001-5555 Large granular lymphocytes (LGLs) are medium-to-large cells, of either Tor natural killer (NK)-cell lineage, characterized by eccentric nuclei, condensed chromatin, and abundant pale cytoplasm containing coarse azurophilic granules (1, 2). Proliferative conditions of Tand NKLGLs represent a complex spectrum of different clini...

In previous studies, ILA has been reported to interfere with IL-2-driven generation of lymphokine-activated killer (LAK) activity. In this investigation, we have demonstrated that IL4 inhibited the IL-2-induced differentiation of large granular lymphocytes (LGL) into LAK effectors by a mechanism involving, at least in part, an increase in LGL intracellular cAMP levels. In contrast, with its cap...

BACKGROUND Invasive aspergillosis involving patients with neutropenia or severe immunosuppression, such as patients with hematologic malignancies is associated with high mortality. Patients with T-cell large granular lymphocytic leukemia (T-LGL) on the other hand are considered to be less vulnerable for severe opportunistic fungal infection as their course of disease is chronic and marked by le...

In contrast to the several antigenic markers identified on murine natural killer (NK) 1 cells (1-3), human NK cells have so far been characterized only by surface properties and receptors (4, 5) that do not allow discrimination from many other peripheral blood mononuclear cells. Detection of human NK cells is therefore largely based on the measurement of in vitro cytolytic reactivity against ce...