INTRODUCTION Hyperinsulinism associated with Beckwith-Wiedemann syndrome (BWS) can occur in about 50% of cases, causing hypoglycemia of variable severity. Parenteral use of octreotide may be indicated if unresponsive to diazoxide. There is limited data on use of octreotide in BWS. OBJECTIVE Chart review describing 2 cases with BWS and hypoglycemia treated with long acting Octreotide as a mont...

Yalnızca biçimbilgisel düzeyde ve süreçlerle değil; sözdizimsel, sözlüksel, edimbilgisel başkaca düzey de şekillenip ortaya çıkabilen birbirinden bağımsız çok farklı yollarla işaretlenebilen edilgenlik, Türkçede çokluğu ifade etmede kullanılan -lAr ile ikincil olarak işaretlenebilmektedir. Daha üçüncü kişi eylem çekiminde, tüm zamanlarda kiplerde biçimbiriminin edilgenliği işaretleme işlevi, ço...

OBJECTIVE Our laboratory has previously created 2 strains of rabbits with genetically determined high-atherosclerotic response (HAR) and low-atherosclerotic response (LAR). The aim of the present study was to identify new genes of atherosclerosis susceptibility in macrophages from the 2 strains. METHODS AND RESULTS Suppression subtractive hybridization was used to screen for genes with higher...

A novel liquid argon (LAr) purity monitor was developed with a sensitivity to elec-tronegative impurities of the order of ppb (O 2 equivalent). Such a high purity is e.g. needed in a LAr drift chamber. The principle is to measure the lifetime of quasifree electrons in LAr, since this is the important parameter for the operation of a drift chamber. Free electrons are produced by ionizing the LAr...

Patients with nonresectable metastatic neuroendocrine tumors (NETs) experience symptoms of hormone hypersecretion including diarrhea, flushing, and bronchoconstriction, which can interfere with quality of life [Anthony and Vinik (2011) Pancreas, 40:987]. Treatment with a long-acting release formulation of octreotide, a somatostatin analog, can help to alleviate these symptoms. Although high dos...

BACKGROUND Local allergic rhinitis (LAR) is a phenotype of allergic rhinitis characterized by the presence of a localized immune response in the nasal mucosa of patients with negative skin prick test (SPT) results and undetectable serum specific IgE (sIgE). It unknown whether LAR is limited to areas with low or moderate aeroallergen exposure. OBJECTIVE To explore the presence of LAR and the c...

many patients are referred to the allergy clinic long after disease onset. In 2014, we published the initial results of a 10-year follow-up study of LAR [8] . We included a cohort of 194 LAR patients (<2 years of evolution) and 130 healthy controls evaluated yearly. After 5 years, patients and controls had a similar rate of conversion to SAR (6.8 and 4.5%, respectively). These data contrast wit...

Abbreviations: DSCG: Disodium Cromoglycate; BPT: Bronchial Provocation Test; SPT: Skin Prick Test; BU: Biologic Unit; FVC: Forced Vital Capacity; FEV1: Forced Expiratory Value in 1 Second; IAR: Immediate (Early) Asthmatic Response; LAR: Late Asthmatic Response; DLAR: Dual Late Asthmatic Response (a combination of IAR and LAR); DYAR: Delayed Asthmatic Response; DDYAR: Dual Delayed Asthmatic Resp...

A fundamental step in the evolution of the visual system is the gene duplication of visual opsins and differentiation between the duplicates in absorption spectra and expression pattern in the retina. However, our understanding of the mechanism of expression differentiation is far behind that of spectral tuning of opsins. Zebrafish (Danio rerio) have two red-sensitive cone opsin genes, LWS-1 an...

There are few effective, safe modalities for the management of Graves' ophthalmopathy (GO), a cell-mediated immune comorbidity of thyroid disease. Somatostatin analogs inhibit lymphocyte proliferation and activation, and accumulate in the orbital tissue of patients with GO. A double-blind, placebo-controlled study of a long-acting somatostatin analog [16 wk of long-acting release formulation of...