Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease in developed countries. Obesity is the most important risk factor for metabolic syndrome and NAFLD. Accumulated evidence has revealed that gut microbial compositional changes may be associated with more energy harvesting from the diet, which promotes increased fatty acid uptake from adipose tissue and shifts l...

BACKGROUND Although it is known that losing weight has an effect on the treatment of non-alcoholic fatty liver disease, the studies that show how losing weight affects the non-alcoholic fatty liver disease for the normal weight male adults are limited so far. In this study, we set body mass index as criteria and investigated how the weight changes for 4 years makes an impact on the risk of non-...

Non-alcoholic fatty liver disease (NAFLD) represents a spectrum of conditions characterized by macrovesicular hepatic steatosis in the absence of significant alcohol intake (less than 20 gm/day for males and 10 gm/day for females). Two main histological patterns are recognized: 1. Steatosis without inflammation; and 2. steatohepatitis (NASH) with inflammation, fibrosis and cirrhosis. NAFLD is a...

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in Western countries, but the disease profile has not yet been described in South Africa. NAFLD affects all spheres of society, especially the poorest and least educated. Aim. To investigate the demographics and clinical and biochemical features of South African patients diagnosed with non-alcoholic...