Autism is a severe developmental disorder whose neurological basis is largely unknown. The aim of this study was to identify the shape differences of the corpus callosum between patients with autism and control subjects. Anatomical landmarks were collected from midsagittal magnetic resonance images of 25 patients and 18 controls. Euclidean distance matrix analysis and thin-plate spline analyses...

This article presents methods for the analysis and decomposition of multivariate datasets where a given ordering/structure of the observations or the variables exist. Examples of such data sets are remote sensing imagery where observations (pixels) each consisting of a reflectance spectrum are organised in a two-dimensional grid. Another example is biological shape analysis. Here each observati...

A large number of registration techniques rely on manually selected landmark points. A system based on neural principles has been developed to automatically extract landmark types and positional information from magnetic resonance images. A single self-organising map is used to develop the features (landmark types) so that the final landmarks represent statistically significant contour sections...

Four experiments examined 3- and 4-year-olds' ability to communicate about containment and proximity relations. One hundred twenty-eight children either described where a miniature mouse was hiding in a dollhouse or they searched for the mouse after the experimenter described where it was hiding. The mouse was always hidden with a small landmark that was either in or next to a large landmark. W...