The nature and content of lytic bodies and the localization of acid phosphatase (AcPase) activity were investigated in mammotrophic hormone-producing cells (MT) from rat anterior pituitary glands. MT were examined from lactating rats in which secretion of MTH(1) was high and from postlactating rats in which MTH secretion was suppressed by removing the suckling young. MT from lactating animals c...

Apixaban, a potent and highly selective factor Xa inhibitor, is currently under development for treatment of arterial and venous thrombotic diseases. The distribution, metabolism, and elimination of [C]apixaban were investigated in male, female, pregnant, and lactating rats after single oral doses. Tissue distribution of radioactivity in rats was measured using quantitative whole-body autoradio...

The metabolism of antibody-excess immune complexes was compared in lactating and normal female BALB/c mice. The initial rate of clearance of the antigen, dinitrophenyl- (DNP) ovalbumin, when complexed with mouse anti-DNP antibody was considerably faster in lactating mice. The half-life was 4 min in lactating mice compared with 8 min in normal female mice. Tissue distribution studies revealed th...

BACKGROUND Convincing evidence exist that carnitine synthesis and uptake of carnitine into cells is regulated by peroxisome proliferator-activated receptor α (PPARA), a transcription factor which is physiologically activated during fasting or energy deprivation. Sows are typically in a negative energy balance during peak lactation. We investigated the hypothesis that genes involved in carnitine...

Intravenous infusions of glucose and/or glucagon-like peptide-1(7-36)-amide (GLP) or somatostatin-28 (S28) were administered to dry and lactating sheep and changes in plasma glucose and serum insulin were followed before, during and after infusion. Basal serum insulin concentrations were significantly lower in lactating sheep but there was no significant difference in plasma glucose concentrati...

A survey was conducted in Southwestern, Punjab, Pakistan during two different seasons to assess the status of selenium of three different classes of grazing sheep. Blood plasma from lactating, non-lactating and male sheep were collected four times monthly in winter and summer seasons and analyzed for selenium concentration. Seasonal variations were found for plasma selenium concentration. Selen...

The lactating mammary gland utilizes free plasma amino acids as well as those derived by hydrolysis from circulating short-chain peptides for protein synthesis. Apart from the major route of amino acid nitrogen delivery to the gland by the various transporters for free amino acids, it has been suggested that dipeptides may also be taken up in intact form to serve as a source of amino acids. The...

The histological study was carried out on mammary glands collected from 14 Madras red sheep, 7 in lactating period 7 in non-lactation period. The connective tissue became reduced and lobuloalveolar tissue was predominantly increased during lactating period. The alveoli were laminated, filled with secretion and lined by cuboidal active secretory cells containing lipid droplets and protein granul...

Lactation embodies a natural model of morphological, neurochemical, and functional brain plasticity. In this reproductive stage, the hippocampus of the female is less sensitive to excitotoxins in contrast to nulliparity. Growth hormone (GH) and insulin-like growth factor 1 (IGF1) are known to be neuroprotective in several experimental models of brain lesion. Here, activation of the GH-IGF1 pitu...