نتایج جستجو برای: lactate dehydrogenase ldh

تعداد نتایج: 94215  

Journal: :The Journal of biological chemistry 1972
E Goldberg

Lactate dehydrogenase (LDH) X has been isolated in crystalline form from mouse testes. Homogeneity of the protein preparation was established by disc gel electrophoresis, analytical ultracentrifugation, and immunochemical analyses. LDH-X is clearly distinct in amino acid composition from LDH-1 and LDH-5 with respect to numbers of residues of leucine, glycine, threonine, and methionine. When 6 t...

Journal: :Advances in peritoneal dialysis. Conference on Peritoneal Dialysis 2006
Satoshi Ogata Masahiro Mori Yorimitsu Tatsukawa Kei Kiribayashi Noriaki Yorioka

In patients on long-term continuous ambulatory peritoneal dialysis, the efficiency of dialysis declines because of peritoneal neovascularization and loss of peritoneal mesothelial cells. In this study, we investigated the influence of lactate and bicarbonate in peritoneal dialysis fluid on such changes of the peritoneum. We studied the production of vascular endothelial growth factor (VEGF) and...

ژورنال: طب مکمل 2018

IIntroduction: Creatine is one of the most important and commonly used supplements among athletes, although the molecular mechanisms by which it exerts its effect and its side effects are less understood. The aim of this study was to determine the effect of creatine monohydrate supplementation on the activity of creatine kinase and dehydrogenase enzymes after an intense exercise test in athleti...

Journal: :Immuno 2021

Serum lactate dehydrogenase (LDH) levels are inversely related with response to immune checkpoint inhibitors (ICIs) in patients metastatic melanoma. LDH is a key regulator of glycolysis, pathway known be upregulated malignant tumors and negatively affect antitumor immunity. We hypothesized that isotype distribution peripheral blood better reflects tumor glycolytic activity than total might ther...

Journal: :Clinical chemistry 2008
Giampaolo Cattozzo Elena Guerra Ferruccio Ceriotti Carlo Franzini

BACKGROUND The availability of commutable calibrator materials may ease considerably the task of harmonizing assay results and ensuring their traceability to reference procedures. We sought to verify the commutability of potential calibrator materials and evaluate their effectiveness in harmonizing LDH results by 2 measurement methods. METHODS We measured LDH in 109 serum samples and 31 mater...

Deyhim, M.R., Jahanshahi Ghajar, ُS., Rafiee, M.H., Sotoudehnejad Nematollahi, F.,

Abstract Background and Objectives There is a circadian rhythm and diurnal variation in the redox capacity in blood plasma and there is a decrease in antioxidant capacity (TAC) during the RBCs storage in blood banking. So it is possible that donated blood, based on donation time, has a different antioxidant capacity and as a result a different biochemical response during storage. This study at...

Journal: :Journal of analytical toxicology 1995
C L Winek W W Wahba

Gas chromatography is considered to be the reference method for ethyl alcohol determination. However, enzymatic ethanol assays have been developed for use in the clinical laboratory by several commercial vendors. Essentially, these assays utilize the oxidation of ethyl alcohol to acetaldehyde with concurrent reduction of nicotinamide adenine dinucleotide (NAD) to NADH while monitoring the incre...

Journal: :Molecular biology and evolution 1997
H Mannen S C Tsoi J S Krushkal W H Li S S Li

The cDNAs encoding lactate dehydrogenase isozymes LDH-A (muscle) and LDH-B (heart) from alligator and turtle and LDH-A, LDH-B, and LDH-C (testis) from pigeon were cloned and sequenced. The evolutionary relationships among vertebrate LDH isozymes were analyzed. Contrary to the traditional belief that the turtle lineage branched off before the divergence between the lizard/alligator and bird line...

Journal: :Plant physiology 1986
N E Hoffman A D Hanson

Using Affigel Blue and oxamate-agarose affinity chromatography, lactate dehydrogenase (LDH) was purified 2000-fold from hypoxically induced barley roots. Molecular weights of the native and sodium dodecyl sulfate-denatured LDH protein were 157 and 40 kilodaltons, respectively, indicating a tetramer. Purified barley LDH was very similar in size and kinetic properties to potato LDH. However, thei...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
O Dym E A Pratt C Ho D Eisenberg

d-Lactate dehydrogenase (d-LDH) of Escherichia coli is a peripheral membrane respiratory enzyme involved in electron transfer, located on the cytoplasmic side of the inner membrane. d-LDH catalyzes the oxidation of d-lactate to pyruvate, which is coupled to transmembrane transport of amino acids and sugars. Here we describe the crystal structure at 1.9 A resolution of the three domains of d-LDH...

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