The metallo-lactamase (MBL) GIM-1, first identified in Pseudomonas aeruginosa isolates in Germany in 2002 (1), has since been described sporadically and never outside Germany in Pseudomonas spp. (2, 3), Acinetobacter pittii (4), and a range of Enterobacteriaceae (3, 5, 6). No genetic variations of blaGIM-1 have been reported (7). The Enterobacter cloacae isolate described here was first identif...

Clinically significant NDM-1-producing Acinetobacter schindleri has not yet been described in the literature. We report the first case of bacteraemia due to an A. schindleri strain harbouring blaNDM-1 recovered from an immunocompromised patient. Our report reinforces the fact that NDM-1 can easily be acquired by Acinetobacter species.

Carbapenem-resistant Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Acinetobacter baumannii were isolated from a single patient, each producing different carbapenemases (NDM-1, KPC-2, IMP, and OXA-23, respectively). The NDM-1-producing E. coli strain was preceded by a clonally related carbapenem-susceptible strain a month earlier, suggesting in vivo acquisition of blaNDM-1.

background :   ampc beta lactamases play a significant role in creating resistance to third generation cephalosporins worldwide. they mostly express on chromosome of enterobacteriaceae especially escherichia coli and cause consequential problem in clinical treatment and lead to failure in diagnosis and phenotypic test recommended by clinical and laboratory standards institute.   methods : total...

Hospitals and wastewater treatment plants (WWTPs) are high-risk point sources of antibiotic-resistance genes (ARGs) antibiotic-resistant bacteria. This study investigates the occurrence clinically relevant ARGs (sul1, tet(B), blaCTX-M, blaNDM-1, qnrS) a class one integron (intI1) gene in urban rivers, hospitals, municipal Kathmandu Valley, Nepal. Twenty-five water samples were collected from th...

INTRODUCTION Infections caused by Pseudomonas aeruginosa are difficult to treat as the majority of isolates exhibit varying degrees of beta-lactamase mediated resistance to most of the beta-lactam antibiotics. It is also not unusual to find a single isolate that expresses multiple beta-lactamase enzymes, further complicating the treatment options. Thus the present study was designed to investig...