The title compound, C(12)H(17)NO(3), adopts a folded conformation with a C-C(NH(2))-C(=O)-O torsion angle of -95.9 (2)°. In the crystal, mol-ecules are linked by an O-H⋯N hydrogen bond, forming helical chains along the b-axis direction. Weak N-H⋯O and C-H⋯O hydrogen bonds are observed between the chains.

The present study demonstrates the utility of an in vitro-in vivo correlative approach in the selection of an optimum prodrug candidate of L-767,679 (N-([7-(piperazin-1-yl)-3,4-dihydro-1(1H)-isoquinolinone-2-yl]acetyl)-3(S)-(ethynyl)-beta-alanine), a potent fibrinogen receptor antagonist. As an initial screening step, a comparative in vitro hepatic metabolism study was conducted for L-767,679 a...

There is considerable experimental evidence in support of the view that, in solution, the state of molecular dispersion of insulin is dependent on the net charge of the protein (10, 6, 8). In these investigations, alterations of the net positive charge were obtained by varying the pH of the solutions, with due consideration of the effect of the specific binding affinity of the protein for anion...

To discern the mechanism(s) that underlie abnormal cholesteryl ester transfer (CET) in patients with hypercholesterolemia, we have studied this dysfunctional step in reverse cholesterol transport in 13 subjects with genetically heterogeneous forms of hypercholesterolemia (HC). In all HC patients, the mass of CE transferred in whole plasma from HDL to VLDL and LDL increased rapidly initially and...

THE TITLE COMPOUND [SYSTEMATIC NAME: (methoxy-carbonyl-meth-yl)ammonium chloride], crystallizes as a salt, C(3)H(8)NO(2) (+)·Cl(-), with the charged species inter-acting mutually via strong and highly directional N(+)-H⋯Cl(-) hydrogen bonds which lead to the formation of a supra-molecular tape running parallel to the c axis. Tapes close pack in the solid state mediated by multipoint recognition...

This work presents the effect of nanoparticles (Al2O3 and TiO2) on methyl ester synthesized from palm kernel oil for oil-filled power equipment. It investigates loss tangent, AC conductivity, breakdown strength ester-based nanofluid. The surface was functionalized with oleic acid before dispersing it into to modify stability mixture. Scanning electron microscopy coupled dispersive X-ray done tw...

Syntheses of several diorganodiselenides and, in particular, a seven-membered cyclic seleninate ester derived from 2-phenoxyethanol are described. The seleninate ester was obtained from allyl (2-(2-hydroxyethoxy)phenyl) selenide through a series of oxidation and [2,3] sigmatropic rearrangement steps. The ester exhibits good GPx-like activity in the coupled reductase assay.