In this study, we aimed to investigate the peripheral antinociception effects of specificphosphodiesterase 5 (PDE-5) inhibitor vardenafil on carrageenan-induced nociception in rats,and the role of calcium besides the L-arginine- nitric oxide (NO)- cyclic guanosine monophophate(cGMP) pathway in these effects. Hyperalgesia was induced by the intraplantar injection of 0.1mL fresh carrageenan solut...

BACKGROUND & OBJECTIVES Malaria is a life-threatening disease caused by Plasmodium parasites. The life-cycle of Plasmodium species involves several stages both in mosquito and the vertebrate host. In the erythrocytic stage, Plasmodium resides inside the red blood cells (RBCs), where it meets most of its nutritional requirement by degrad- ing host's haemoglobin. L-arginine is required for growth...

Abstract Background and Aims Autosomal Dominant Polycystic Kidney Disease (ADPKD) is an inherited, complex disease, cystogenesis phenotypic changes in this disorder being not yet fully understood. Recently, arginine, important for renal cells metabolism, was proved to play role ADPKD physiopathology (1). The inability of recycle or synthesize intracellular arginine through the urea cycle define...

Arginine kinase (adenosine 5'-triphosphate: L-arginine phosphotransferase, EC 2.7.3.3) was purified from the larvae of the tobacco hornworm, Manduca sexta (L). This enzyme catalyzes the production of L-phosphoarginine, which is the principal reserve of high energy phosphate compounds in insect muscle. The enzyme also phosphorylates L-canavanine, a guanidinooxy analogue of arginine which severel...

Intrauterine growth retardation (IUGR) is associated with vascular complications leading to hypoxia and abnormal fetal development. The effect of IUGR on L-arginine transport and nitric oxide (NO) synthesis was investigated in cultures of human umbilical vein endothelial cells (HUVECs). IUGR was associated with membrane depolarization and reduced L-arginine transport (V(max)= 5.8+/-0.2 versus 3...

a b s t r a c t introduction: mercury is the second most metal pollutant in the world and has the potential to induce many pathologic conditions, especially in nervous system, such as depression. here we tried to find out if nitric oxide has any possible role in the pathophysiology of depression induced by this metal. although the role of nitric oxide has been shown in mood control, here we use...

Introduction: The aim of the present study was to determine direct effects of NO modulation on protective electrophysiological properties of atrioventricular node (AV node) in the experimental model of AF in rabbit. Methods: Isolated perfused rabbit AV nodal preparations were used in two groups. In the first group (N=7), LNAME (50μM) was applied. In the second group (N=12), different concent...

The renal basic amino acid metabolism often differs in rodents, strict carnivores, and omnivore species. Given the pivotal role of L-arginine and L-ornithine in several metabolic pathways and the fact that the dog is closely related to humans, being also an omnivore, we tested whether L-arginine metabolism and L-ornithine catabolism take place in the dog kidney. We examined the metabolism of L-...

Introduction: L-Arginine supplementation improves antioxidant defenses through L-Arginine/nitric oxide pathways. This investigation assesses the influences of acuteL-Arginine supplementation on selected markers of delayed onset muscle soreness (DOMS) after one by one heavy eccentric exercise in healthy young females. Methods: Twelve healthy young females students of the University of Mohaghegh...