THE SMALL GTPase Rho has three isoforms, RhoA, RhoB, and RhoC, of which RhoA has been widely studied. When the Rho gene was first cloned in 1980s, the physiological function of Rho was thought to be similar to its relatives, the Ras proteins. Unexpectedly, Rho was soon found to be crucial in the regulation of the actin cytoskeleton (10, 11). In the following years, many Rho downstream targets w...

Despite evidence that weathering plays a role in forming intertidal, estuarine, and fluvial rock platforms, many publications uncritically refer to “wave-cut” or “stream-cut” rock platforms. The alternative explanations of chemical weathering and physical water erosion of rock platforms have been debated since 1839. Our new approach to this long-standing problem introduces data from fluvial as ...

In this article, we provide the first third-party security analysis of the PRINCE lightweight block cipher, and the underlying PRINCEcore. First, while no claim was made by the authors regarding related-key attacks, we show that one can attack the full cipher with only a single pair of related keys, and then reuse the same idea to derive an attack in the single-key model for the full PRINCEcore...

Peroxisome proliferator-activated receptor-γ (PPARγ) and Rho-kinase (ROCK) regulate smooth muscle cell (SMC) proliferation and contribute to vascular remodeling in adult pulmonary hypertension. Whether these pathways interact to contribute to the development of vascular remodeling in persistent pulmonary hypertension of the newborn (PPHN) remains unknown. We hypothesized that ROCK-PPARγ interac...

I lied to the future last night. I told it that soon it would be big and strong and profitable. I then tucked it into its crib, turned off the lights, and hoped the day would never come when the future would curse this lie. I not only assured the future it would someday be strong and profitable, I also told it how it would strong and profitable. My lie was a little more prosaic than my words su...

Recently, a RGB image encryption algorithm based on DNA encoding and chaos map has been proposed. It was reported that the encryption algorithm can be broken with four pairs of chosen plain-images and the corresponding cipher-images. This paper re-evaluates the security of the encryption algorithm, and finds that the encryption algorithm can be broken efficiently with only one known plain-image...

Rho-associated kinase (ROCK) I mediates signaling from Rho to the actin cytoskeleton. To investigate the in vivo functions of ROCK-I, we generated ROCK-I-deficient mice. Loss of ROCK-I resulted in failure of eyelid closure and closure of the ventral body wall, which gave rise to the eyes open at birth and omphalocele phenotypes in neonates. Most ROCK-I(-/-) mice died soon after birth as a resul...

27 Using projective and objective measures, effects of rock music on emotion were investigated. Sixty students were randomly assigned to three conditions: hard rock, soft rock, and no music. One group listened to hard rock music while taking a projective test with five ink blots and an objective test with an Emotional Assessment Scale (EAS). The same procedure was used for the second group whil...

The homologous mammalian rho kinases (ROCK I and II) are assumed to be functionally redundant, based largely on kinase construct overexpression. As downstream effectors of Rho GTPases, their major substrates are myosin light chain and myosin phosphatase. Both kinases are implicated in microfilament bundle assembly and smooth muscle contractility. Here, analysis of fibroblast adhesion to fibrone...

The evaluation of local stability of the tunnel surrounding rock mass with weak rock layer is very important for the economy and security of the tunnel construction. Based on the rock tunnel geological conditions in the construction, the finite element model of the tunnel surrounding rock mass stability analysis with weak rock layer is established in the article by selecting the ABAQUS program ...