Ablation of the mouse genes for Onecut-2 and Onecut-3 was reported previously, but characterization of the resulting knockout mice was focused on in utero development, principally embryonic development of liver and pancreas. Here we examined postnatal development of these Onecut knockout mice, especially the critical period before weaning. Onecut-3 knockout mice develop normally during this per...

Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality worldwide but only a few FDA-approved drugs are available for advanced HCC patients. Immune checkpoint inhibitor (ICI) has emerged as new and effective treatment HCC, yet quarter patients responsive to ICI treatment. Epigenetic deregulation plays critical role in initiation progression whereas contribution histone...

Aspartokinase III, encoded by lysC, is responsible for the first step of lysine biosynthesis in Escherichia coli. In this study, a lysC knockout E. coli W3110 strain was generated to study the differential gene expression profiles of wild type and lysC knockout strains. Several significant changes were observed, including biosynthesis of lysine, oxaloacetate, alpha-ketoglutarate and glutamate g...