نتایج جستجو برای: kir3dl1

تعداد نتایج: 213  

2016
E. Townsley G. O'Connor C. Cosgrove M. Woda M. Co S. J. Thomas S. Kalayanarooj I.‐K. Yoon A. Nisalak A. Srikiatkhachorn S. Green H. A. F. Stephens E. Gostick D. A. Price M. Carrington G. Alter D. W. McVicar A. L. Rothman A. Mathew

Killer immunoglobulin-like receptors (KIRs) interact with human leucocyte antigen (HLA) class I ligands and play a key role in the regulation and activation of NK cells. The functional importance of KIR-HLA interactions has been demonstrated for a number of chronic viral infections, but to date only a few studies have been performed in the context of acute self-limited viral infections. During ...

Journal: :Journal of immunology 2015
Hiroko Hatano Jacqueline Shaw Kaitlin Marquardt Zhiyong Zhang Laurent Gauthier Stephanie Chanteux Benjamin Rossi Demin Li Julie Mitchell Simon Kollnberger

We proposed that the killer cell Ig-like receptor KIR3DL2 binding more strongly to HLA-B27 (B27) β2-microglobulin free H chain (FHC) dimers than other HLA-class I molecules regulates lymphocyte function in arthritis and infection. We compared the function of B27 FHC dimers with other class I H chains and identified contact residues in KIR3DL2. B27 FHC dimers interacted functionally with KIR3DL2...

2016
Christiane Maria Ayo Fábio Batista Frederico Rubens Camargo Siqueira Cinara de Cássia Brandão de Mattos Mariana Previato Amanda Pires Barbosa Fernando Henrique Antunes Murata Aparecida Perpétuo Silveira-Carvalho Luiz Carlos de Mattos

The objective of this study was to investigate the influence of the genes encoding the KIR receptors and their HLA ligands in the susceptibility of ocular toxoplasmosis. A total of 297 patients serologically-diagnosed with toxoplasmosis were selected and stratified according to the presence (n = 148) or absence (n = 149) of ocular scars/lesions due to toxoplasmosis. The group of patients with s...

2016
Ralph D Levinson Madeline Yung Akira Meguro Elham Ashouri Fei Yu Nobuhisa Mizuki Shigeaki Ohno Raja Rajalingam

Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells are killer lymphocytes that provide defense against viral infections and tumor transformation. Analogous to that of CTL, interactions of killer-cell immunoglobulin-like receptors (KIR) with specific human leukocyte antigen (HLA) class I ligands calibrate NK cell education and response. Gene families encoding KIRs and HLA ligands are lo...

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