The aim of the study is to determine level HIF-1α, TNF-α, and NF-kB in hippocampus kindled rats treated with rapamycin axitinib.
 Materials methods. Kindling was produced 29 by administration three-week pentylenetetrazole (PTZ, 35.0 mg/kg, i.p.). Treatment (0.5 i.p.) axitinib (2.5 performed for ten days fully rats. avidin-biotin-peroxidase method used hippocampal slice staining. For negati...

The maternal form of modern rabbit crosses is obtained by crossing ancestral lines. Therefore it relevant to investigate the effect using males parental line Hyla cross with different weight indices on performance main breeding traits female rabbits cross. purpose study was level productivity reproduction signs and consider dynamics for a number births. experiments used 223 cross, which came fr...

Repeated administration of pentylenetetrazol (PTZ 30 mg/kg, thrice a week) to mice for 9 weeks and subsequent challenge of the animals with the same dose of PTZ on the last chronic dose produced chemical kindling. The mice showed myoclonic jerks, clonus, Straub’s tail, falling back response and full-blown convulsions. The anticonvulsant profile of chronic administration of BR16A (100 and 500 mg...

Amygdala kindling is commonly used to study the mechanisms involved in epileptogenesis, with long-term amygdala kindling providing a useful model of the behavioural disturbances— such as heightened anxiety— that can occur between epileptic seizures. The purpose of this thesis was to determine whether increased fear behaviours exhibited by long-term amygdala kindled rats are reflective of previo...

Introduction: Application of low-frequency stimulation (LFS) is a new method for treatment of drug resistant epileptic patients. Previous studies demonstrated that activation of receptors coupled to Gi proteins is one of the mechanisms of the anticonvulsant effect of LFS. Thus, in this study, alterations in the expression of RGS4 and RGS10 proteins, as negative regulators of Gi proteins, wer...

Progesterone plays a key role in ovarian cycle-related synaptic plasticity and neuronal excitability. Progesterone receptors (PRs), which mediate the cellular actions of progesterone, are expressed in the hippocampus and other limbic regions, but their functional significance remains unknown. Here, we report a novel role of PRs as crucial mediators in the development of epileptogenesis, which i...

Mesial temporal lobe epilepsy (MTLE), the most common epilepsy in adults, is generally intractable and is suspected to be the result of recurrent excitation or inhibition circuitry. Recurrent excitation and the development of seizures have been associated with aberrant mossy fiber sprouting in the hippocampus. Of the animal models developed to investigate the pathogenesis of MTLE, post-status e...

Kindling refers to a phenomenon where an initially subthreshoid electrical stimulation applied repeatedly (daily) to the different brain structures results in the progressive development of electroclinical seizures terminating in a generalized convulsion (4, 6). It has been suggested that the kindling effect may be employed as a model of epilepsy (3, 6, 10) and epileptogenesis (7) as a neuronal...