background: the organochlorine ddt has estrogenic activity but the mechanism underlying the estrogenic activity of this pesticide remains unclear. in the present investigation here, we studied the transcriptional effects of a synthetic organochlorine pesticide o,p’-ddt [1.1.1.-trichloro-2-(o-chlorophenyl)-2-p-chloriphenyl ethane] and its metabolite p,p'-dde (2-2-bis(4/chlorophenyl)-1-1-dic...

objective(s): acquisition of tnf-α resistance plays role in the onset and growth of malignant tumors. previous studies have demonstrated that mcf-7 cell line and its doxorubicin resistant variant mcf-7/adr are resistant against the cytotoxic effects of tnf-α. in this study, we investigated the role of akt activation in resistance of mcf-7 and mcf-7/adr against tnf-α cytotoxicity. materials and ...

nitric oxide (no) is thought to be involved in spatial learning and memory in several brain areas such as hippocampus. this study examined the effects of post-training intrahippocampal microinjections of 1400w as a selective inducible nitric oxide synthase (inos) inhibitor on spatial memory, in both anesthetized and non-anesthetized situations in rats. in the present work, 4-day training trials...

stress is one of the effective factors in the development of depressive disorders that performs some parts of its effects by affecting hippocampus. since doxepin has been shown to have neuroprotective effects, in this study, we focused on the effects of doxepin on the expression of involved genes in neuronal survival and plasticity in the rat hippocampus following chronic stress. male wistar ra...

The original online version of this article (Guo, R., Wang, X., Zhang, R., Shi, H., Qiao, Y., Yun, W., Ge, Lin, Y. and Lei, J. (2015) Response Subcutaneous Xenografts of Endometrial Cancer in Nude Mice to Inhibitors Phosphatidylinositol 3-Kinase/Akt Mitogen-Activated Protein Kinase (MAPK) Pathways: An Effective Therapeutic Strategy for Endometrial Cancer. Journal Therapy, 6, 1083-1092. htt...

Qing’E pills are a classical formula in traditional Chinese medicine that has the effect of tonifying kidneys and strengthening bones, first appearing tonic formulae prescriptions peaceful benevolent dispensary (10th century CE). To preliminarily elucidate potential mechanisms treatment postmenopausal osteoporosis based on network pharmacology. The principal components corresponding protein tar...

Background: Novel roles for the interaction of cardiotonic steroids to Na+/K+-ATPase have been established in recent years. The aim of the present study was to investigate the intracellular signaling events downstream the action of ouabain on Na+/K+-ATPase in Sertoli cell obtained from immature rats. Treatment of Sertoli cells with ouabain (1 μM) induced a rapid and transient increase in the ex...

Phellodendrine is a Phellodendri Cortex-derived isoquinoline alkaloids, has been shown to have various activities, especially hypoglycemic effect in mice, predicting its medicinal value on diabetes mellitus. To further understand the pharmacological of phellodendrine mellitus, network techniques used elaborate involved mechanisms. 84 common target molecules were screened, based chemical structu...

Background: Alzheimer’s disease (AD) is the most important neurogenerative disorder with progressive dementia as its main clinical manifestation. The microRNAs (miRNAs) are identified crucial modulators in AD progression. Nevertheless, biological potential of miR-21 obscure. Hence, this study aimed to evaluate possible role pathogenesis via phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/...