objective: dalbegia saxatilis (d.saxatilis) is used as a decoction in traditional medicine for ailments such as cough, small pox, skin lesions, bronchial ailments and toothache. this study is aimed at evaluating the toxic effect of methanol leaf extract of d.saxatilis on renal function. materials and methods: wistar rats of both sexes were divided into four groups of five: control animals (grou...

BACKGROUND Although a reduced glomerular filtration rate (GFR) in old people has been attributed to physiologic aging, it may be associated with kidney disease or superimposed comorbidities. This study aims to assess the prevalence of decreased GFR in a geriatric population in a developing country and its prevalence in the absence of simultaneous diseases. STUDY DESIGN AND METHODS This is a c...

background: according benefcial effects of  tribulus terrestris  (tt) extract on  tissue damage, the present study investigated the infuence of hydroalcoholic extract of tt plant on cisplatin (cis) (ebewe pharma, unterach, austria) induced renal tissue damage in male mice. methods: thirty mice were divided into five groups (n = 6). the first group (control) was treated with normal saline (0.9% ...

BACKGROUND Inflammation plays a crucial role in kidney damage after crush syndrome (CS). Several researchers report that high mobility group box-1 protein (HMGB1) may be the vital trigger in kidney damage, and tumor necrosis factor-α (TNF-α) and c-Jun N-terminal kinase (JNK) are involve in this pathophysiological process, but their biological roles are unclear. This study aimed to explore the r...

Background: The widely adopted Jablonski scoring system for reporting histological damage in kidney ischaemia reperfusion injury (IRI) provides a limited score documenting the degree of necrosis within tubular cells. IRI is a complex process that involves damage to various cellular components of the renal cortex and therefore there is a need to develop a more detailed scoring system. The aims o...

Two patients with transient hypercalcaemia during recovery from acute renal failure are described. The literature is reviewed and possible pathophysiological mechanisms discussed. Patients with renal failure following muscle damage should have regular measurement of plasma calcium.

Ochratoxin A (OTA) is a potent nephrotoxin and renal carcinogen in rats, but the mechanism of OTA tumorigenicity is unknown. Ochratoxin A has been shown to be negative in many genetic toxicology test in vitro. However, the potential of OTA to induce genotoxic effects has not been investigated in male rats, the most sensitive species for OTA-induced tumor formation. In this study, male F344 rats...

CKD is recognized worldwide as an important problem in children. The overt stage of CKD is end-stage renal disease, which is merely the tip of the iceberg of a large number of “covert less severe diseases.” CKD represents a developing process that is initiated by various causes, all with the common end result of persistent and usually progressive damage of varying severity to the kidneys. It is...

background caroli disease is a rare inherited disorder characterized by dilatation of the intrahepatic bile ducts. the presented case is a female middle age patient that during clinical and para-clinical evaluation for an unrelated compliant found that has caroli disease. although, the disease is hereditary but the family history was negative. after three years follow up, no involvement of kidn...

Oxidative stress may contribute to the pathogenesis of diabetic nephropathy. However, the detailed molecular mechanism remains uncertain. Here, we report oxidative mitochondrial DNA (mtDNA) damage and accumulation of mtDNA with a 4,834-bp deletion in kidney of streptozotocin-induced diabetic rats. At 8 weeks after the onset of diabetes, levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), which is a...