BACKGROUND To evaluate the predictive and prognostic value of various molecular factors associated with the Ras/MAPK and PI3K/Akt signaling pathways in HER2-positive locally advanced breast cancer patients treated with anthracycline-based neoadjuvant chemotherapy (NAC). METHODS A total of 113 patients were recruited in this retrospective study. Core needle biopsies and excision samples were a...

BACKGROUND Ameloblastoma is an odontogenic neoplasm characterized by local invasiveness and tendency towards recurrence. AIMS Studying the role played by EGFR, CD10 and Ki67 in the recurrence of ameloblastoma. METHODS This study was carried out on 22 retrospective cases of mandibular ameloblastoma from the period from Jan 2002 to Jan 2008 with follow up period until Jan 2011 (3 to 8 years f...

PURPOSE To examine the molecular profile of fetal human retinal progenitor cells (hRPCs) expanded in vitro and those grown in a co-culture system with mouse retina through the analysis of protein and gene expression and neurotransmitter-stimulated calcium dynamics. METHODS hRPCS were isolated from human retina of 14 to 18 weeks gestational age (GA) and expanded in vitro. Immunoblot, microarra...

has high incidence and poor prognosis requiring early screening of high-risk populations. Minichromosome maintenance (MCM) proteins are used as diagnosticbiomarkers in many cancers but not validated for GCC. We evaluate MCM protein 2 (MCM2), comparing it with the validated markers Ki67 and PCNA. Methods: GCC and corresponding cardiac precancerous samples were immunostained with Ki67, MCM2 and P...

The aim of the present study was to investigate Ki67 expression level and measure cell proliferation index (Ki67) in odontogenic benign tumors. This an analytical cross-sectional sampling non-probabilistic with exhaustive recruitment including all biopsy or surgical excision specimen immunohistochemistry performed on histological sections paraffin-fixed tissues 3µ thickness (MM1) monoclonal ant...

Objective: To investigate the effect and clinical significance of myeloid-derived suppressor cells (MDSCs) levels serum miRNA-21 expression in advanced non-small cell lung cancer (NSCLC) patients. Methods: Advanced NSCLC patients treated at First People’s Hospital Tongxiang City, Zhejiang Province, between July 2021 June 2022 were included this study. MDSCs peripheral circulation assessed by fl...

BACKGROUND Recent studies have showed a significant association between the combination of COX-2, p16 and Ki67 overexpression and incidence of subsequent invasive carcinoma in a subgroup of treated ductal carcinoma in situ (DCIS) and the indicated prognostic value of COX-2, p16 and Ki67 in early breast cancer. Based on the continual model of carcinogenesis and the mentioned results, we hypothes...

Background: Worldwide gall bladder cancer (GBC) is known to be the commonest malignant tumour of biliary tract. It most aggressive carcinoma tract with short median survival from time diagnosis. The biologic behaviour and non-availability sensitive screening tests for early detection may responsible poor prognosis associated GBC.
 Material Methods: Patients diagnosed neoplastic non-neoplas...

In this study, the proliferative activity of human B and T cell precursors in central lymphoid organs, acute lymphoblastic leukemia (ALL) cells, and permanent cell lines was investigated with double- and triple-color-labeling methods for the analysis of cell cycle-associated features such as 5-bromo-2'-deoxyuridine (BrdU) incorporation and the expression of a nuclear proliferation-associated an...