Micelle with mesomeric polyleucine (PDLLeu) core demonstrated the most uniform morphology, the smallest diameter and the highest drug loading capability compared to those with dextrorotatory (PDLeu), levorotatory (PLLeu) and racemic PLeu (PD/LLeu) cores. In addition, the modification with c(RGDfC) endowed the optimal PDLLeu micelle with enhanced intracellular drug release and cytotoxicity, indi...

Herein, we report a biocompatible amphiphilic block copolymer micelle bearing a singlet oxygen-sensitive vinyldithioether cleavable linker at the core-shell junction, which undergoes singlet oxygen-mediated photocleavage in the presence of visible light. The micelle facilitates the light-responsive release of singlet oxygen and an anticancer drug for enhanced photodynamic therapy.

As an alternative to cell specific cancer targeting strategies (which are often afflicted with the heterogeneity of cancer cells as with most biological systems), a novel polymeric micelle constitute of two block copolymers of poly(L-lactic acid)-b-poly(ethylene glycol)-b-poly(L-histidine)-TAT (transactivator of transcription) and poly(L-histidine)-b-poly(ethylene glycol) was developed. The mic...

acanthophyllum laxiusculum is one of the most widely distributed species of the genus in iran that flourishes in steppe and mountainous regions of the country. in the present study, water-soluble content of a. laxiusculum roots was extracted by boiling water and further successively purified partially by a defined solvent system. surface tension measurements revealed the ability of plant extrac...

Supramolecular carriers such as micelles can be used to noncovalently bind drug molecules for pharmaceutical applications. However, these carriers can fundamentally affect diffusion-based drug transport due to host-guest coupled diffusion. We report a ternary interdiffusion study on an ionic drug in aqueous micellar solutions. Specifically, high-precision Rayleigh interferometry was used to det...

Novel nanosized lead tungstate (PbWO4) hollow spindles were successfully synthesized, for the first time, via a Pluronic P123- (EO20PO70EO20-) assisted sonochemical process. The triblock copolymer acted as a structure-directing agent and played a key role in the formation of the hollow spindles. An in situ micelle templating mechanism has been proposed for the possible formation mechanism of th...

The interactions of DNA with oxaliplatin (Pt(R,R-DACH)) or its enantiomer (Pt(S,S-DACH)) were investigated using magnetic tweezers and atomic force microscope. In the process of DNA condensation induced by Pt-DACH, only diadducts and micro-loops are formed at low Pt-DACH concentrations, while at high Pt-DACH concentrations, besides the diadducts and micro-loops, long-range cross-links are also ...

We report the development of an automated chemical reactor for solid-phase synthesis of MIP NPs in water. Operational parameters are under computer control, requiring minimal operator intervention. In this study, "ready for use" MIP NPs with sub-nanomolar affinity are prepared against pepsin A, trypsin and α-amylase in only 4 hours.

In just a matter of months, SARS-CoV-2 had spread around the world. Scientists collaborate to solve problem. The development antiviral drugs is challenge in itself due rapidly changing nature virus. Selection drug candidates can be done quickly through repurposing method. Broad-spectrum may strong for therapy. Nanotechnology one solution delivery systems. advantages possessed by nanoparticle sy...