Koyun karbonik anhidraz-II (E.C: 4.2.1.1) enzimi koyun karaciğerinden saflaştırıldı ve bazı karakteristik özellikleri araştırıldı. Enzim 4000 EU/mg protein spesifik aktivitesi ve % 38.6 verim ile yaklaşık olarak 43,1 kat saflaştırıldı. Enzim için optimum pH, optimum sıcaklık, optimum iyonik şiddet ve stabil pH sırasıyla 7.5, 40oC, 10 mM ve 8.5 olarak belirlendi. Moleküler ağırlığı sodyum dodesi...

j J Am Med Inform Assoc. 2005;12:418–430. DOI 10.1197/jamia.M1701. In a recent report, the Institute of Medicine listed decision support as one of eight core capabilities that a successful electronic health record should incorporate to promote greater safety, quality, and efficiency in health care. At the heart of most modern decision support systems are two key components: an inference engine ...

Methods For a 3 months period we have studied all cases of primary and secondary bacteremia occurred in patients hospitalized in ICU of KAT Hospital in Athens. The patients’ demographic data, the reason of admission, the day when bacteremia occurred, the cultured microbe and its resistance to antibiotics as well as the duration of patients’ hospitalization in ICU have been recorded. The statist...

This study explores the influence of test repetition on bipodal visually controlled balance, both static and dynamic. Our goal was to get an insight into the pattern of changes in posture maintenance results during repeated balance tests. Fifteen young, healthy male recreational athletes were tested for static and for dynamic balance using KAT 2000 balance platform. The subjects first performed...

Companion Modelling (ComMod) is an iterative approach of modelling in interaction with local stakeholders. KatAWARE is a multi-agent model constructed through a ComMod process with the Water User Association of the Kat River Valley, Eastern Cape, South Africa. By describing the construction of the KatAWARE model, the aim of this paper is to propose a detailed methodology to formalize and to sys...

Lowering of tumor interstitial hypertension, which acts as a barrier for tumor transvascular transport, has been proposed as a general strategy to enhance tumor uptake and therapeutic effects of anticancer drugs. The tyrosine kinase platelet-derived growth factor (PDGF) beta-receptor is one mediator of tumor hypertension. The effects of PDGF antagonists on chemotherapy response were investigate...

The MYST family of lysine acetyltransferases (KATs) function in a wide variety of cellular operations, including gene regulation and the DNA damage response. Here we report the characterization of the second MYST family KAT in the protozoan parasite Toxoplasma gondii (TgMYST-B). Toxoplasma causes birth defects and is an opportunistic pathogen in the immunocompromised, the latter due to its abil...

The primary headache disorders include migraine, which is one of the most frequent neurological disorders, which influences more than 14% of the whole population. Despite the research efforts, its exact pathomechanism is not fully revealed, but evidence points to the role of glutamate and its receptors. Kynurenic acid is an endogenous glutamate receptor antagonist produced by the kynurenine pat...