The activities of pyruvate dehydrogenase (PDH) kinase and of PDH kinase activator protein (KAP) were increased 2-2.4-fold during 25 h of culture of hepatocytes from fed rats with glucagon plus n-octanoate. PDH kinase activity in hepatocytes from starved rats (initially 2.2 x fed control) fell during 25 h of culture in medium 199 (to 1.5 x fed control), but was maintained by glucagon plus octano...

The karyopherin (Kap) family of nuclear transport factors facilitates macromolecular transport through nuclear pore complexes (NPCs). The binding of Kaps to their cargos can also regulate, both temporally and spatially, the interactions of the cargo protein with interacting partners. Here, we show that the essential yeast Kap, Kap121, binds Dam1 and Duo1, components of the microtubule (MT)-asso...

We present single-molecule confocal microscopy studies of orientational distributions for luminophores isolated in potassium hydrogen phthalate (KAP) crystals. The incorporation of dye molecules that bear no size or shape similarity to the host ions is observed, demonstrating that single-molecule studies on mixed crystals need not be restricted to isomorphous host/guest pairs. Violamine R is or...

1Department of Internal Medicine; 2Department of Family and Community Medicine; 3Department of Urology, College of Medicine, King Faisal University, Dammam, Saudi Arabia. Received: 06/05/03; accepted: 19/11/03 ABSTRACT We aimed to test the knowledge, attitude and practice (KAP) of physicians towards erectile dysfunction in the Eastern province of Saudi Arabia. At a scientific meeting about erec...

Background: Improper nutritional knowledge is one of the most important causes of nutritional problems, which can affect practice and cause more complications. The aim of this study was to assess the association between nutritional knowledge, attitude and practice (KAP) of Iranian households with socioeconomic status (SES).   Methods: The study population was 14,136 households (57 clust...

Transforming a well vectorized Fortran77 CFD code into a more flexible Fortran90 program using a hybrid parallelization model still is an adventure. Here we report on our experiences with PANTA, a 3D Navier-Stokes solver that is extensively used in the modeling of turbomachinery. During this ongoing process various software tools are employed: Hewlett Packard's, Silicon Garphics', Portland Grou...

This paper critically examines current parallel programming practice and optimising compiler development. The general strategies employed by compiler and programmer to optimise a Fortran program are described, and then illustrated for a speciic case by applying them to a well known scientiic program, TRED2, using the KSR-1 as the target architecture. Extensive measurement is applied to the resu...

Choosing a probability distribution to represent the precipitation depth at various durations has long been a topic of interest in hydrology. Early study into the distribution of wet-day daily rainfall has identified the 2-parameter Gamma (G2) distribution as the most likely candidate distribution based on traditional goodness of fit tests. This paper uses probability plot correlation coefficie...

Adaptive algorithms based on kernel structures have been a topic of significant research over the past few years. The main advantage is that they form a family of universal approximators, offering an elegant solution to problems with nonlinearities. Nevertheless these methods deal with kernel expansions, creating a growing structure also known as dictionary, whose size depends on the number of ...