نتایج جستجو برای: k562

تعداد نتایج: 4081  

Journal: :Marine Drugs 2008
Dexin Kong Shunji Aoki Yoshihiro Sowa Toshiyuki Sakai Motomasa Kobayashi

Smenospongine, a sesquiterpene aminoquinone isolated from the marine sponge Dactylospongia elegans, was previously reported by us to induce erythroid differentiation and G1 phase arrest of K562 chronic myelogenous leukemia cells. In this study, we investigated the effect of smenospongine on the cell cycles of other leukemia cells, including HL60 human acute promyelocytic leukemia cells and U937...

Journal: :Blood 1985
H N Steinberg A S Tsiftsoglou S H Robinson

The human leukemic cell lines K562 and HL-60 were cocultured with normal bone marrow (BM) cells. Coculture with 10(4) K562 or HL-60 cells results in 50% inhibition of normal CFU-E and BFU-E colony formation. However, when the same number of K562 and HL-60 cells is first treated for two to five days with agents that induce their differentiation, a gradual loss in their capacity to inhibit CFU-E ...

Journal: :The Journal of pharmacology and experimental therapeutics 2007
Sang Min Lee Jae Ho Bae Mi Ju Kim Hyun Sun Lee Min Ki Lee Byung Seon Chung Dong Wan Kim Chi Dug Kang Sun Hee Kim

Bcr-Abl-independent signaling pathways are known to be involved in imatinib resistance in some patients with chronic myelogenous leukemia (CML). In this study, to find new targets for imatinib-resistant CML displaying loss of Bcr-Abl kinase target dependence, we isolated imatinib-resistant variants, K562/R1, K562/R2, and K562/R3, which showed profound declines of Bcr-Abl levels and its tyrosine...

ژورنال: :مجله دانشگاه علوم پزشکی کردستان 0
سید محمد امین موسوی seyed mohammad amin moosavi zoology dept., faculty of natural science, university of tabriz, tabriz, iranگروه زیست شناسی جانوری، دانشکده علوم طبیعی، دانشگاه تبریز، تبریز، ایران امیر حسین احمدی amir hosein ahmadi msc student, dept., of zoology, faculty of natural science, university of tabriz, tabriz, iranدانشجوی کارشناسی ارشد، گروه زیست شناسی جانوری، دانشکده علوم طبیعی، دانشگاه تبریز، تبریز، ایران

چکیده زمینه و هدف: آدنوزین ́5- تری فسفات (atp) نه تنها به عنوان منبع رایج انرژی در تمامی سلول ها به شمار می رود، بلکه در تحریک مسیرهای پیام رسانی داخل سلولی نیز که منجر به آپوپتوز و یا تمایز می شود نیز، نقش ایفا می کند. در طول سالیان گذشته گزارش های متعددی درباره اثرات ضد سرطانی این ترکیب بر رده های سلولی سرطان های مختلف ارائه شده است. همچنین چندین مکانیسم در مورد نحوه عملکرد atp ارائه شده است و...

Journal: : 2022

Despite its efficacy, radiation therapy faces the challenges connected with accelerated reproduction of tumor cells and radioresistance malignant neoplasms.
 The aim study was to analyze impact gene expression level intermolecular interaction networks on development cell radioresistance.
 Materials Methods. authors used 4 lines: (K562, HCT-116p53 (+/+), (–/–), Me45. To line transcript...

Journal: :Clinical lymphoma, myeloma & leukemia 2015
Ceyda Tunakan Dalgıç Burçin Tezcanlı Kaymaz Melda Cömert Özkan Ayşegül Dalmızrak Fahri Şahin Güray Saydam

We aimed to evaluate the cytotoxic and apoptotic effects of dasatinib (BMS-354825) on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on dasatinib-induced apoptosis. The results showed that dasatinib decreased proliferation and induced apoptosis in K562 cells in a dose- and time-dependent manner. mRNA and protein levels of STAT5A and STAT5B genes were significan...

Journal: :Nucleic acids research 2000
T H Li C Kim C M Rubin C W Schmid

Alu repeats in K562 cells are unusually hypomethylated and far more actively transcribed than those in other human cell lines and somatic tissues. Also, the level of Alu RNA in K562 cells is relatively insensitive to cell stresses, namely heat shock, adenovirus infection and treatment with cycloheximide, which increase the abundance of Alu RNA in HeLa and 293 cells. Recent advances in understan...

Journal: :Blood 1996
J P Liuzzo D Moscatelli

Basic fibroblast growth factor (bFGF) has been identified as an important cytokine for blood cells. To determine whether hematopoietic cells have receptors that recognize bFGF, the ability of human leukemia cell lines to bind 125I-bFGF was investigated. Specific bFGF-binding sites were identified on K562 and HL60 cells, but not on U937 cells. DAMI cells bound low amounts of 125I-bFGF specifical...

سلیمانی آهویی, طاهره , شعبانزاده, مسعود, بی خوف تربتی, مریم , خسروی, فاطمه , صفری, مژده,

سابقه و هدف : مشتقات کینوکسالین و پیرازولین دارای طیف وسیعی از اثرات بیولوژیکی می باشند که آنها را به عوامل دارویی مناسبی با اثرات مختلف از جمله خاصیت سایتوتوکسیک در شیمی درمانی سرطان تبدیل کرده است. در این مطالعه ترکیب ′ 5-فنیل- ′ 2و ′ 4-دی هیدرو اسپایرو[ایندنو[1و2- b ]کینوکسالین-11و ′ 3-پیرازول] سنتز شد و اثرات سایتوتوکسیک آن بر روی رده سلولی K562 و سلولهای PBMC بررسی گردید. مواد و روش ها : ت...

Journal: :Blood 1982
A M Gewirtz D Burger T A Rado E J Benz R Hoffman

The human leukemia cell line K562 was derived from a patient with chronic granulocytic leukemia. This cell line has subsequently been shown to possess phenotypic markers typical of erythroid and myeloid cells. Using a rabbit antiserum directed against purified platelet glycoproteins (PGPs), we have obtained evidence for the constitutive expression of PGPs on the surface of K562 cells. PGPs expr...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید