Keratinocytes and other epithelial cells express two receptors for the basement membrane (BM) extracellular matrix component laminin-5 (Ln-5), integrins alpha 3 beta 1 and alpha 6 beta 4. While alpha 3 beta 1 mediates adhesion, spreading, and migration (Kreidberg, J.A. 2000. Curr. Opin. Cell Biol. 12:548--553), alpha 6 beta 4 is involved in BM anchorage via hemidesmosomes (Borradori, L., and A....

In this paper, we show that an NPR M -channel filter bank with a diagonal system inserted between the analysis and synthesis filter banks may be used to decompose an FIR system of order L into M complex subband components each of order L K , where K is the downsampling rate. This decomposition is at the expense of using complex arithmetic for the subband processing. The theory surrounding the p...

We analyze in detail directivity enhancement in imaging with small arrays of closely spaced sensors, in homogeneous media. Imaging is done with Kirchhoff or travel time migration of the array data after applying an inverse filter that increases the resolution of the image. In general, the construction of such a filter requires invasive measurements on a control array in the vicinity of the obje...

Potassium channels selectively conduct K(+) ions across cellular membranes with extraordinary efficiency. Their selectivity filter exhibits four binding sites with approximately equal electron density in crystal structures with high K(+) concentrations, previously thought to reflect a superposition of alternating ion- and water-occupied states. Consequently, cotranslocation of ions with water h...

This paper investigates the output and state trajectories of a third-order digital filter with two’s complement arithmetic realized in parallel form. Although the output of the thirdorder digital filter seems to behave randomly, some regular patterns can be displayed on the plot of y (k − 1) versus y (k), where those regular patterns are similar to the second-order case. When the first-order su...

Structures of the prokaryotic K(+) channel, KcsA, highlight the role of the selectivity filter carbonyls from the GYG signature sequence in determining a highly selective pore, but channels displaying this sequence vary widely in their cation selectivity. Furthermore, variable selectivity can be found within the same channel during a process called C-type inactivation. We investigated the mecha...

Human lung mast cells (HLMC) express the Ca(2+)-activated K(+) channel K(Ca)3.1, which plays a crucial role in their migration to a variety of diverse chemotactic stimuli. K(Ca)3.1 activation is attenuated by the beta(2)-adrenoceptor and the adenosine A(2A) receptor through a G(s)-coupled mechanism independent of cyclic AMP. Prostaglandin E(2) promotes degranulation and migration of mouse bone ...