IgM ACPA 6 (20) 11 (37) 13 (43) Introduction We and others have previously shown that the development of rheumatoid arthritis (RA) is preceded by IgG anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF) [1,2]. Furthermore, it was shown that other isotypes of ACPA (IgA and, to a lesser extent, the IgM isotype) also predate the onset of RA [3]. Moreover, smoking has been linked t...

The literature of the last 4 years confirms that the anti-CCP2 test is a very useful marker for the early and specific diagnosis of rheumatoid arthritis (RA). The anti-CCP2 test is very specific for RA (95-99%) and has sensitivity comparable to that of the rheumatoid factor (70-75%). The antibodies can be detected very early in the disease and can be used as an indicator for the progression and...

Dr. Jones has in this volume, with the sub-title, comprising " Rheumatoid Arthritis, Osteo-arthritis, and Spondylitis Deformans," given a most excellent epitome of present-day knowledge of the diseases of the rheumatoid class. Agreeing with most modern workers, he makes a sharp distinction between the two' diseases, rheumatoid arthritis and osteo-arthritis, nor does he believe that the former m...

This study aimed to understand the meaning of the experience of families having a child experiencing pain due to Juvenile Rheumatoid Arthritis and to construct a theoretical model representing this experience. Grounded Theory and Symbolic Interactionism were used as methodological framework and theoretical framework, respectively. Data were collected by semistructured interviews with 12 familie...

Early diagnosis of rheumatoid arthritis is essential for its proper management. Currently, the initial phase of rheumatoid arthritis is known to provide a window of therapeutic opportunity. Although the diagnosis is primarily clinical, the development and improvement of laboratory and imaging methods have contributed to earlier diagnosis and determination of procedures in early rheumatoid arthr...