In this article, three alternative Bayesian hierarchical latent factor models are described for spatially and temporally correlated multivariate health data. The fundamentals of factor analysis with ideas of space- time disease mapping to provide a flexible framework for the joint analysis of multiple-related diseases in space and time with a view to estimating common and disease-specific trend...

Haplotype inference from phase-ambiguous multilocus genotype data is an important task for both disease-gene mapping and studies of human evolution. We report a novel haplotype-inference method based on a coalescence-guided hierarchical Bayes model. In this model, a hierarchical structure is imposed on the prior haplotype frequency distributions to capture the similarities among modern-day hapl...

An automated method for two-dimensional spatial depiction (mapping) of quantitative physiological tissue characteristics derived from contrast-enhanced MRI was applied to a model of inflammatory disease represented by antigen-induced arthritis of the temporomandibular joint in the rabbit. Specifically, an established two-compartment kinetic model of unidirectional mass transport was implemented...

rheumatoid arthritis (ra) is an inflammatory progressive disease which in the absence of appropriate treatment can lead to joint destruction and disability. prognosis of ra may be predicted based on the presence of some clinical and laboratory evidences.new criteria for classification of ra provides opportunity for earlier treatment. initiation of treatment particularly by combination of dmards...

A discussion of the overlap problem of reweighting approaches to evaluating critical phenomenon in fermionic systems is motivated by highlighting the divergence of the joint probability density function of a general ratio. By identifying the bounds for which this integral can be expressed in closed form, we establish criteria for accurately mapping the joint ratio distribution of two disjoint e...

In this technical report we treat some properties of the recently introduced QBGvalue function. In particular we show that it is a piecewise linear and convex function over the space of joint beliefs. Furthermore, we show that there exists an optimal infinite-horizon QBG-value function, as the QBG backup operator is a contraction mapping. We conclude by noting that the optimal Dec-POMDP Q-value...

With the increasing availability of functional genomic data (Consortium et al., 2012, Kundaje et al., 2015, Ardlie et al., 2015), incorporating genomic annotations into QTL mapping has become a standard analytical procedure. However, the existing analysis methods often lack rigor and/or computational efficiency. We present a novel algorithm to perform integrative multi-SNP QTL mapping in a prob...

The eigenvalues of an arbitrary quaternionic matrix have a joint probability distribution function first derived by Ginibre. We show that there exists a mapping of this system onto a fermionic field theory and then use this mapping to integrate over the positions of the eigenvalues and obtain eigenvalue density as well as all higher correlation functions for both the strongly and weakly non-Her...

background brucellosis as a zoonotic infectious disease is endemic in iran and due to the variation in clinical and laboratory findings, its diagnosis is often delayed. objectives the aim of this study was to determine clinical and laboratory aspects of the disease in khuzestan. patients and methods medical records of 81 admitted patients with a diagnosis of brucellosis were reviewed. the study...