PURPOSE: Inhibition of insulin-like growth factor (IGF) signaling using the human IGF-I receptor monoclonal antibody A12 is most effective at inducing apoptosis in prostate cancer xenografts in the presence of androgen. We undertook this study to determine mechanisms for increased apoptosis by A12 in the presence of androgens. Experimental Methods: The castrate-resistant human xenograft LuCaP 3...

The permeability transition in human mitochondria refers to the opening of a nonspecific channel, known as the permeability transition pore (PTP), in the inner membrane. Opening can be triggered by calcium ions, leading to swelling of the organelle, disruption of the inner membrane, and ATP synthesis, followed by cell death. Recent proposals suggest that the pore is associated with the ATP synt...

1930 yılından günümüze uzanan aerojeller; Guinness rekorlar kitabına giren en hafif ve katı malzeme olarak seçilmiştir. Yüksek ısıl absorbsiyon özelliği, çok iyi yalıtkanlık kabiliyeti, mezo gözenek yapısı mukavemetinin yüzey alanının yüksek olması gibi üstünlüklerinin birçok malzemeye alternatif kullanım avantajı sektörde olanağı sunmaktadır. Bu çalışmada, sol-jel tekniği kullanılarak saflıkta...

We have investigated the effect of electromechanical activity on the molecular forms of acetylcholinesterase (AChE) in cultured embryonic rat myotubes. Both globular and asymmetric forms of AChE are present on the 5th day of culture when myotubes are just beginning to fibrillate. Between days 5 and 8, the 4 S (G1), 10 S (G4), and 16 S (A12) forms increase dramatically, and appreciable 12.5 S (A...

Összefoglaló. Egy 47 éves nőbeteg tranziens ST-eleváció miatt került felvételre és coronarographiára. A ST-elevációnak véleményezett elektrokardiogram poroszsisak-jelnek felelt meg, amelyet egy EKG-műtermék okozott. Habár a számtalan, nem coronariaeredetű oka ismert, műtermék okozta poroszsisak-jelet még ismertettek. Fontos felismerése felesleges diagnosztikai terápiás beavatkozások elkerülése ...