Yes-associated protein (YAP) has been shown to play a critical role in the growth of various tumours. Phosphorylation of Ser127 of YAP leads to the inhibition of YAP translocation into nucleus and subsequent failure to regulate the expression of target genes that induce cell proliferation. Chemical manipulation of YAP localization or expression may provide an efficient method for cancer treatme...

Cells internalize extracellular solutes, ligands and proteins and lipids in the plasma membrane (PM) by endocytosis. The removal of membrane from the PM is counteracted by endosomal recycling pathways that return the endocytosed proteins and lipids back to the PM. Recycling to the PM can occur from early endosomes. However, many cells have a distinct subpopulation of endosomes that have a mildl...

We prove that given a real JB*-triple E, and a real Hilbert space H , then the set of those bounded linear operators T from E toH , such that there exists a norm one functionalφ ∈ E∗ and corresponding pre-Hilbertian semi-norm ‖.‖φ on E such that ‖T (x)‖ ≤ 4 √ 2‖T‖ ‖x‖φ for all x ∈ E, is norm dense in the set of all bounded linear operators from E toH . As a tool for the above result, we show th...

OBJECTIVES Some changes are found in the labyrinth anatomy during postnatal development. Although the spatial orientation of semicircular canals was thought to be stable after birth, we investigated the age-related orientational changes of human semicircular canals during development. METHODS We retrospectively studied the computed tomography (CT) images of both ears of 76 subjects ranged fro...

Arylnaphthalene lignan lactones have attracted considerable interest because of their anti-tumor and anti-hyperlipidimic activities. However, to our knowledge, few studies have explored the effects of these compounds on human leukemia cell lines. In this study, five arylnaphthalene lignans including 6'-hydroxy justicidin A (HJA), 6'-hydroxy justicidin B (HJB), justicidin B (JB), chinensinaphtho...

Antigen-specific suppression to poly(Glu50-Tyr50) (GT) is under the control of two complementary immune suppressor (Is) genes located in the major histocompatibility (H-2) complex of the mouse. Suppressor strains of mice produce both suppressor T (Ts) cells and Ts-derived suppressor factors (TsF) that bear antigenic determinants of the I-J subregion of the H-2 complex. Nonsuppressor strains of ...

INTRODUCTION In virally induced cancers, nuclear factor jB (NF-jB) transcription factors that promote neoplastic transformation are aberrantly activated, and antiviral innate and adaptive immune responses often are deregulated. However, to our knowledge, the nature and role of the genetic changes required for sustained infection and transformation and their clinical consequences are less clear....

doi:10.1111/febs.13547 Modification of proteins with Met1-linked ‘linear’ ubiquitin chains has emerged as a key regulatory signal to control inflammatory signalling via the master regulator, the transcription factor nuclear factor jB (NF-jB). While the assembly machinery, the linear ubiquitin chain assembly complex (LUBAC), and receptors for this ubiquitin chain type have been known for years, ...