BACKGROUND LFA-1/JAM-A interaction plays a significant role in early steps of leukocyte transendothelial migration (diapedesis) which takes part in atherosclerosis pathogenesis. In this population-based case-control study, the frequencies of JAM-A rs790056 and LFA-1 rs8058823 gene polymorphisms in patients with coronary heart disease (CHD) and healthy subjects were investigated and the correlat...

OBJECTIVE SSc is characterized by microvascular abnormalities and leucocyte infiltration. Previous studies have suggested a proadhesive phenotype in SSc skin, but the functional consequences of this phenotype are not fully understood. Molecules known to mediate leucocyte adhesion include those present at intracellular junctions, such as junctional adhesion molecule-B (JAM-B), JAM-C and CD99, as...

in this research, the effect of water stress on the soluble sugars, starch and proteins content of two different cultivars (kaka and jam) of chickpea (cicer arietinum) was studied. the results showed that the soluble sugars increased while starch decreased during the stress in shoot and root of both cultivars. increasing of soluble sugars and decreasing of starch hall a positive correlation wit...

In this issue of Neuron, Redmond et al. (2016) identify junction adhesion molecule 2 (JAM2) as an inhibitor of somatodendritic myelination in spinal cord neurons, thereby elucidating how myelin forms on axons but avoids dendrites and cell bodies.

The minaret and archaeological remains at Jam, in central Afghanistan, were nominated as Afghanistan's first World Heritage site in 2002. The nomination was successful despite the International Council on Monuments and Sites (ICOMOS)'s reservations about the quality and completeness of the nomination document: in particular, ICOMOS was concerned about the rudimentary mapping and imprecise defin...

Virus attachment to cells plays an essential role in viral tropism and disease. Reovirus serotypes 1 and 3 differ in the capacity to target distinct cell types in the murine nervous system and in the efficiency to induce apoptosis. The binding of viral attachment protein sigma1 to unidentified receptors controls these phenotypes. We used expression cloning to identify junction adhesion molecule...