In previously treated head-and-neck cancer patients, p.o. administered isotretinoin (13-cis retinoic acid) reduced the occurrence of second aerodigestive tumors, including lung tumors, but side effects made chronic therapy problematic. We reasoned that inhaled isotretinoin might provide sufficient drug to the target cells for efficacy while avoiding systemic toxicity, and we proceeded with the ...

OBJECTIVE To assess the risk of attempted suicide before, during, and after treatment with isotretinoin for severe acne. DESIGN Retrospective cohort study linking a named patient register of isotretinoin users (1980-9) to hospital discharge and cause of death registers (1980-2001). SETTING Sweden, 1980-2001. Population 5756 patients aged 15 to 49 years prescribed isotretinoin for severe acn...

Objective: Isotretinoin is highly preferred in the treatment of severe and resistant acne, but there are still disagreements about whether it has psychogenic side effects. In this study; we aim to investigate changes psychological symptoms before after a group patients treated with isotretinoin. Material Methods: A total 110 who had moderate or decided start isotretinoin treatment, were include...

Patients with acne often develop neuropsychiatric disorders of varying severity, correlating, as a rule, the severity dermatosis. Isotretinoin is most commonly used drug for treatment moderate acne. Due to fact that in number studies isotretinoin was considered trigger development various disorders, numerous were conducted prove this possibility or refute it. An analysis literature showed that,...

Clinical Question: Recently, one of our patients who was taking isotretinoin became pregnant. This occurred despite appropriate counseling, a negative pregnancy test result before commencing treatment, and use of the combined oral contraceptive pill Microgynon 30 (Schering Health Care, West Sussex, England) (levonorgestrel, 150 μg, ethinylestradiol, 30 μg). The patient did not want to terminate...

Retinoids are of particular interest in experimental and clinical oncology. They exert their antitumor activity through inhibition of cell proliferation, induction of cell differentiation, suppression of oncogene expression and inhibition of angiogenesis. In animal experiments, retinoids have preventive and therapeutic effects on premalignant and malignant lesions. Clinically, chemoprevention w...

Isotretinoin (Accutane) ranks in the top 10 of the US Food and Drug Administration's database of drugs associated with reports of depression and suicide attempts. However, this association is still controversial because up to 5.6% of patients with moderate acne may have pre-existing suicidal ideations, improvement of acne often reduces associated depression, and isotretinoin users are reportedl...

Isotretinoin is a drug indicated in dermatology for the treatment of acne and used off-label for other skin and mucosal disorders. Most patients treated with isotretinoin develop mild adverse effects that do not affect the course of treatment. However, it can have less common unpredictable effects that are more serious and must be known by those who habitually use this drug in clinical practice...