A 62-year-old woman developed pruritus, oedema, erythema and vesiculation, well demarcated at the application sites of nitroglycerin TTS on the trunk and upper arms (Fig. 1). Lesions healed with post-inflammatory hyperpigmentation. Two weeks before, the patient had started treatment for coronary insufficiency with daily nitroglycerin transdermal patches (Dermatrans 5®, Recordati group, Madrid, ...

NO donor drugs (eg, isosorbide mononitrate; ISMN) and phosphodiesterase 5 inhibitors (eg, sildenafil) have antihypertensive properties, and the combination can markedly reduce blood pressure (BP). The objective of this "proof-of-concept" study was to investigate the effect on BP of a combination of single oral doses of sildenafil (50 mg) and ISMN (10 mg) in patients with treatment-resistant hyp...

INTRODUCTION In this work we report on the possible effect of the medical therapy on CDT concentration in a chronic alcohol abuser, with known medical history (July 2007 - April 2012) and alcohol abuse confirmed by relatives. CASE HISTORY At the end of 2007, patient displayed the following laboratory results: AST 137 U/L, ALT 120 U/L, GGT 434 U/L, MCV 101 fL and CDT 3.3%. On December 2007, af...

BACKGROUND Atrial structural remodeling creates a substrate for atrial fibrillation (AF), but the underlying signal transduction mechanisms are unknown. This study assessed the effects of ACE inhibition on arrhythmogenic atrial remodeling and associated mitogen-activated protein kinase (MAPK) changes in a dog model of congestive heart failure (CHF). METHODS AND RESULTS Dogs were subjected to ...

Male of 67 years of age with a history of ischemic heart disease and bypass graft aorto-biliac currently being treated with clopidogrel, atenolol, isosorbide mononitrate, and statins, who underwent colonoscopy because of general syndrome and anemia. A colonoscopy was performed with sedation medication administered (midazolam 4 mg and fentanyl 0.05 mg) and without complications to report, showin...