The duration of effects of single oral doses of 15, 30 and 60 mg of isosorbide dinitrate (ISDN) were studied in 12 patients with stable, exercise-induced angina pectoris. The effects of a 120-mg dose were also studied in seven of these 12 patients. The average peak values for plasma ISDN concentration were 6.8, 14.3, 17.5 and 26.0 ng/ml after 15, 30, 60 and 120 mg of ISDN, respectively, and the...

In a placebo-controlled trial, we have studied the vasodilator properties of bolus doses of nitroglycerin (TNG) and isosorbide dinitrate (ISDN) in 32 patients during cardiopulmonary bypass with a constant pump flow. Blood volume of the venous reservoir and mean arterial pressure were recorded for 10 min after drug administration to detect changes in venous capacitance and arteriolar resistance,...

We recorded unit activity in the auditory cortex (fields A1, A2, and PAF) of anesthetized cats while presenting paired clicks with variable locations and interstimulus delays (ISDs). In human listeners, such sounds elicit the precedence effect, in which localization of the lagging sound is impaired at ISDs less, similar10 ms. In the present study, neurons typically responded to the leading stim...

The tetra-nuclear title complex, [Cu(4)(C(7)H(4)O(3))(2)(OH)(2)(C(10)H(8)N(2))(4)](NO(3))(2)·4H(2)O, has a crystallographically imposed centre of symmetry. The Cu(II) atoms display a distorted square-pyramidal coordination geometry and are linked by two μ(2)-phenolate O atoms from the salicylate ligands and two μ(3)-hydroxo groups, forming a Cu(4)O(4) core that adopts a 'stepped-cubane' geometr...

The crystal and molecular structure of the title compound,C24H36CoN10O(4).2(NO3).3(H2O).Cl, have been determined by X-ray analysis: Cc (No: 9), a = 17.6920(4) A, b = 11.8163(2) A, c = 16.4752(4) A, Beta = 91.679(1) degrees , Z = 4. The Co(III)ion is six-coordinated with octahedral geometry, the pyridine rings are planar and the piperazine rings assume chair conformations.